Tripathy R, Panda A K, Das B K
Department of Biochemistry, S.C.B. Medical College, Cuttack, Odisha, India.
Institute of Life Sciences, Bhubaneswar, Odisha, India Center for Life Sciences, Central University of Jharkhand, Brambe, Ranchi, Jharkhand, India.
Lupus. 2015 Jan;24(1):82-9. doi: 10.1177/0961203314552290. Epub 2014 Sep 24.
Ferritin is an acute-phase reactant that is elevated in various autoimmune disorders. Serum ferritin levels have been positively correlated with disease activity scores of rheumatoid arthritis and systemic lupus erythematosus (SLE). Further, enhanced levels of ferritin have also been reported in lupus nephritis. However, there are no reports from the Indian subcontinent.
Seventy-six female SLE patients, diagnosed on the basis of revised ACR criteria, and 50 healthy females, age matched from similar geographical areas, were enrolled in the present study. Serum levels of ferritin, IFN-α and IL-6 were quantified by enzyme-linked immunosorbent assay (ELISA). Clinical, biochemical, serological and other markers of disease activity (C3, C4 and anti-dsDNA) were measured by standard laboratory procedure.
Serum ferritin levels were significantly higher in SLE patients compared to healthy controls (p < 0.0001). Ferritin levels positively correlated with SLE Disease Activity Index (SLEDAI) (p = 0.001, r = 0.35), anti-dsDNA (p = 0.001, r = 0.35), IFN-α (p < 0.0001, r = 0.51) and IL-6 (p < 0.0001, r = 0.65) and negatively correlated with C3 (p = 0.0006, r = -0.38) and C4 (p = 0.01, r = -0.28). Interestingly, serum levels of ferritin were positively associated with proteinuria (p = 0.001, r = 0.36), serum urea (p = 0.0004, r = 0.39) and serum creatinine (p = 0.0006, r = 0.38).
Serum ferritin is an excellent marker of disease activity and renal dysfunction in SLE.
铁蛋白是一种急性期反应物，在各种自身免疫性疾病中会升高。血清铁蛋白水平与类风湿关节炎和系统性红斑狼疮（SLE）的疾病活动评分呈正相关。此外，狼疮性肾炎中铁蛋白水平也有所升高。然而，印度次大陆尚无相关报道。
本研究纳入了76名根据修订的美国风湿病学会（ACR）标准确诊的女性SLE患者，以及50名来自相似地理区域、年龄匹配的健康女性。采用酶联免疫吸附测定（ELISA）法对血清中铁蛋白、干扰素-α（IFN-α）和白细胞介素-6（IL-6）水平进行定量。通过标准实验室程序检测疾病活动的临床、生化、血清学及其他指标（C3、C4和抗双链DNA）。
与健康对照组相比，SLE患者的血清铁蛋白水平显著更高（p < 0.0001）。铁蛋白水平与SLE疾病活动指数（SLEDAI）呈正相关（p = 0.001，r = 0.35）、与抗双链DNA呈正相关（p = 0.001，r = 0.35）、与IFN-α呈正相关（p < 0.0001，r = 0.51）、与IL-6呈正相关（p < 0.0001，r = 0.65），与C3呈负相关（p = 0.0006，r = -0.38）、与C4呈负相关（p = 0.01，r = -0.28）。有趣的是，血清铁蛋白水平与蛋白尿呈正相关（p = 0.001，r = 0.36）、与血清尿素呈正相关（p = 0.0004，r = 0.39）、与血清肌酐呈正相关（p = 0.0006，r = 0.38）。
血清铁蛋白是SLE疾病活动和肾功能障碍的良好标志物。
