University Department of Neuroscience, Reproductive Science, Odontostomatology, University of Naples "Federico II", Naples, Italy.
Eur Rev Med Pharmacol Sci. 2017 Jul;21(13):3134-3138.
To evaluate the hormonal profile in three breast cancer patients who underwent controlled ovarian stimulation in the presence of the aromatase inhibitor letrozole.
In IVF University referral center, a case series of three breast cancer patients who underwent controlled ovarian stimulation (COS) with recombinant FSH and letrozole were investigated. Ovulation was induced with hCG (case No. 1) or with GnRH agonist (case No. 2-3). The primary outcome of our study was the detection of progesterone levels in the luteal phase.
Very high progesterone values (mean 186.6 ± 43.6 ng/mL) during the luteal phase were recorded in all three cases.
High progesterone levels can be related to the use of letrozole independently of the most commonly used trigger regimen. Although progesterone has long been considered a protective factor against breast cancer, several studies have demonstrated that progesterone could expand a transformation-sensitive stem cell population in the mammary glands. The estrogen negative feedback effect on the hypothalamus-pituitary axis and the disruption of steroid biosynthesis and could represent an intriguing reason behind this phenomenon. Our results highlight the need to evaluate further the increase in progesterone levels in the luteal phase in women with breast cancer undergoing COS with letrozole.
评估 3 名接受芳香酶抑制剂来曲唑控制性卵巢刺激的乳腺癌患者的激素谱。
在 IVF 大学转诊中心，对 3 名接受重组卵泡刺激素和来曲唑控制性卵巢刺激（COS）的乳腺癌患者进行了病例系列研究。使用 hCG（病例 1）或 GnRH 激动剂（病例 2-3）诱发排卵。我们研究的主要结局是检测黄体期的孕激素水平。
在所有 3 例中，黄体期的孕激素水平非常高（平均值为 186.6±43.6ng/ml）。
高孕激素水平可能与来曲唑的使用有关，而与最常用的触发方案无关。虽然孕激素长期以来被认为是预防乳腺癌的保护因素，但多项研究表明，孕激素可能会扩大乳腺中转化敏感的干细胞群。雌激素对下丘脑-垂体轴的负反馈作用以及类固醇生物合成的破坏可能是这种现象背后的一个有趣原因。我们的结果强调需要进一步评估接受来曲唑 COS 的乳腺癌女性黄体期孕激素水平的升高。
Zotero 插件