阅读着着丝粒表观遗传标记。
Reading the Centromere Epigenetic Mark.
机构信息
Department of Genetics, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Department of Biology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
出版信息
Dev Cell. 2017 Jul 24;42(2):110-112. doi: 10.1016/j.devcel.2017.07.011.
PMID:28742998
Abstract
Centromeres epitomize the central problem of propagating non-DNA sequence-based information across generations. In this issue of Developmental Cell, Hori et al. (2017) and French et al. (2017) show that the centromere-associated protein KNL-2/M18BP1 reads the centromere epigenetic code to maintain centromere identity.
摘要
着丝粒是跨代传播非 DNA 序列信息的核心问题的缩影。在本期《发育细胞》中，Hori 等人（2017 年）和 French 等人（2017 年）表明，与着丝粒相关的蛋白 KNL-2/M18BP1 读取着丝粒的表观遗传密码来维持着丝粒的身份。
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