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Structural origins of clustered protocadherin-mediated neuronal barcoding.簇状原钙黏蛋白介导的神经元条码的结构起源。
Semin Cell Dev Biol. 2017 Sep;69:140-150. doi: 10.1016/j.semcdb.2017.07.023. Epub 2017 Jul 22.
2
Visualization of clustered protocadherin neuronal self-recognition complexes.聚集原钙黏蛋白神经元自我识别复合物的可视化。
Nature. 2019 May;569(7755):280-283. doi: 10.1038/s41586-019-1089-3. Epub 2019 Apr 10.
3
Protocadherin -dimer architecture and recognition unit diversity.原钙黏蛋白二聚体结构与识别单位多样性。
Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):E9829-E9837. doi: 10.1073/pnas.1713449114. Epub 2017 Oct 30.
4
How clustered protocadherin binding specificity is tuned for neuronal self-/nonself-recognition.成簇原钙黏蛋白的结合特异性是如何针对神经元的自我/非自我识别进行调节的。
Elife. 2022 Mar 7;11:e72416. doi: 10.7554/eLife.72416.
5
Molecular logic of neuronal self-recognition through protocadherin domain interactions.通过原钙黏蛋白结构域相互作用实现神经元自我识别的分子逻辑
Cell. 2015 Oct 22;163(3):629-42. doi: 10.1016/j.cell.2015.09.026. Epub 2015 Oct 17.
6
γ-Protocadherin structural diversity and functional implications.γ-原钙黏蛋白结构多样性及其功能意义。
Elife. 2016 Oct 26;5:e20930. doi: 10.7554/eLife.20930.
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Family-wide Structural and Biophysical Analysis of Binding Interactions among Non-clustered δ-Protocadherins.全家族结构与非簇集 δ-原钙黏蛋白结合相互作用的生物物理分析。
Cell Rep. 2020 Feb 25;30(8):2655-2671.e7. doi: 10.1016/j.celrep.2020.02.003.
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Structure and Sequence Analyses of Clustered Protocadherins Reveal Antiparallel Interactions that Mediate Homophilic Specificity.成簇原钙黏蛋白的结构与序列分析揭示了介导嗜同性特异性的反平行相互作用。
Structure. 2015 Nov 3;23(11):2087-98. doi: 10.1016/j.str.2015.09.005. Epub 2015 Oct 15.
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Structural Basis of Diverse Homophilic Recognition by Clustered α- and β-Protocadherins.成簇的α-和β-原钙黏蛋白介导多种同嗜性识别的结构基础
Neuron. 2016 May 18;90(4):709-23. doi: 10.1016/j.neuron.2016.04.004. Epub 2016 May 5.
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Single-cell identity generated by combinatorial homophilic interactions between α, β, and γ protocadherins.由α、β和γ原钙黏蛋白之间的组合性嗜同性相互作用产生的单细胞身份。
Cell. 2014 Aug 28;158(5):1045-1059. doi: 10.1016/j.cell.2014.07.012.
引用本文的文献
1
Surface delivery quantification reveals distinct trafficking efficiencies among clustered protocadherin isoforms.表面递送定量分析揭示了成簇原钙黏蛋白异构体之间不同的转运效率。
Proc Natl Acad Sci U S A. 2025 Aug 5;122(31):e2514178122. doi: 10.1073/pnas.2514178122. Epub 2025 Jul 30.
2
Surface delivery quantification reveals distinct trafficking efficiencies among clustered protocadherin isoforms.表面递送定量分析揭示了成簇原钙黏蛋白亚型之间不同的运输效率。
bioRxiv. 2025 Jun 6:2024.09.23.614616. doi: 10.1101/2024.09.23.614616.
3
Reduced neuronal self-avoidance in mouse starburst amacrine cells with only one isoform.在仅有一种异构体的小鼠星爆无长突细胞中神经元自我回避减少。
bioRxiv. 2025 May 30:2025.05.29.656828. doi: 10.1101/2025.05.29.656828.
4
Structural insights into the in situ assembly of clustered protocadherin γB4.成簇原钙黏蛋白γB4原位组装的结构见解
Nat Commun. 2025 Feb 16;16(1):1682. doi: 10.1038/s41467-025-56948-x.
5
Clustered protocadherin -interactions are required for combinatorial cell-cell recognition underlying neuronal self-avoidance.簇集原钙黏蛋白相互作用对于神经元自我回避所必需的组合细胞间识别。
Proc Natl Acad Sci U S A. 2024 Jul 16;121(29):e2319829121. doi: 10.1073/pnas.2319829121. Epub 2024 Jul 8.
6
Gene choice in cancer cells is exclusive in ion transport but concurrent in DNA replication.癌细胞中的基因选择在离子转运方面是排他性的，但在DNA复制方面是同时发生的。
Comput Struct Biotechnol J. 2024 Jun 10;23:2534-2547. doi: 10.1016/j.csbj.2024.06.004. eCollection 2024 Dec.
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Reciprocal Connections between Parvalbumin-Expressing Cells and Adjacent Pyramidal Cells Are Regulated by Clustered Protocadherin γ.簇状原钙黏蛋白 γ 调控表达 parvalbumin 的细胞与相邻锥体神经元之间的相互联系
eNeuro. 2023 Oct 27;10(10). doi: 10.1523/ENEURO.0250-23.2023. Print 2023 Oct.
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Ubiquitination of the protocadherin-γA3 variable cytoplasmic domain modulates cell-cell interaction.原钙黏蛋白γA3可变胞质结构域的泛素化调节细胞间相互作用。
Front Cell Dev Biol. 2023 Sep 18;11:1261048. doi: 10.3389/fcell.2023.1261048. eCollection 2023.
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Visualization of -interactions of a protocadherin-α between processes originating from single neurons.源自单个神经元的突起之间原钙黏蛋白-α相互作用的可视化。
iScience. 2023 Jul 17;26(7):107238. doi: 10.1016/j.isci.2023.107238. eCollection 2023 Jul 21.
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Structural basis for the self-recognition of sDSCAM in Chelicerata.蛛形纲动物 sDSCAM 自我识别的结构基础。
Nat Commun. 2023 May 2;14(1):2522. doi: 10.1038/s41467-023-38205-1.
本文引用的文献
1
Multicluster Pcdh diversity is required for mouse olfactory neural circuit assembly.多簇原钙黏蛋白多样性是小鼠嗅觉神经回路组装所必需的。
Science. 2017 Apr 28;356(6336):411-414. doi: 10.1126/science.aai8801.
2
Pcdhαc2 is required for axonal tiling and assembly of serotonergic circuitries in mice.Pcdhαc2是小鼠轴突平铺和5-羟色胺能神经回路组装所必需的。
Science. 2017 Apr 28;356(6336):406-411. doi: 10.1126/science.aal3231.
3
γ-Protocadherins Interact with Neuroligin-1 and Negatively Regulate Dendritic Spine Morphogenesis.γ-原钙黏蛋白与神经连接蛋白-1相互作用并负向调节树突棘形态发生。
Cell Rep. 2017 Mar 14;18(11):2702-2714. doi: 10.1016/j.celrep.2017.02.060.
4
Distinct and Cooperative Functions for the -α, -β and -γ Clusters in Neuronal Survival and Axon Targeting.α、β和γ簇在神经元存活和轴突靶向中的独特协同功能
Front Mol Neurosci. 2016 Dec 23;9:155. doi: 10.3389/fnmol.2016.00155. eCollection 2016.
5
Structural determinants of adhesion by Protocadherin-19 and implications for its role in epilepsy.原钙黏蛋白 19 黏附的结构决定因素及其在癫痫中的作用。
Elife. 2016 Oct 26;5:e18529. doi: 10.7554/eLife.18529.
6
γ-Protocadherin structural diversity and functional implications.γ-原钙黏蛋白结构多样性及其功能意义。
Elife. 2016 Oct 26;5:e20930. doi: 10.7554/eLife.20930.
7
The γ-Protocadherin-C3 isoform inhibits canonical Wnt signalling by binding to and stabilizing Axin1 at the membrane.γ-原钙黏蛋白-C3 异构体通过与膜上的 Axin1 结合并稳定其来抑制经典 Wnt 信号通路。
Sci Rep. 2016 Aug 17;6:31665. doi: 10.1038/srep31665.
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Antiparallel protocadherin homodimers use distinct affinity- and specificity-mediating regions in cadherin repeats 1-4.反向平行原钙黏蛋白同型二聚体在钙黏蛋白重复序列1-4中使用不同的亲和力和特异性介导区域。
Elife. 2016 Jul 29;5:e18449. doi: 10.7554/eLife.18449.
9
Structural basis of adhesive binding by desmocollins and desmogleins.桥粒芯蛋白和桥粒芯胶蛋白进行黏附结合的结构基础。
Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):7160-5. doi: 10.1073/pnas.1606272113. Epub 2016 Jun 13.
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Structural Basis of Diverse Homophilic Recognition by Clustered α- and β-Protocadherins.成簇的α-和β-原钙黏蛋白介导多种同嗜性识别的结构基础
Neuron. 2016 May 18;90(4):709-23. doi: 10.1016/j.neuron.2016.04.004. Epub 2016 May 5.
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