关节固定和后肢卸载对大鼠比目鱼肌胶原纤维的影响。
Effects of joint immobilization and hindlimb unloading on collagen fibers of soleus muscles in rats.
作者信息
Matsumoto Tomohiro, Ono Takeya, Ishikura Hideki, Aihara Kazuki, Sato Yuta, Tasaka Atsushi, Umei Namiko, Tsumiyama Wakako, Oki Sadaaki
机构信息
Department of Rehabilitation Science, Kobe University Graduate School of Health Sciences, Japan.
Department of Physical Therapy, Faculty of Health and Welfare, Prefectural University of Hiroshima, Japan.
出版信息
J Phys Ther Sci. 2017 Jul;29(7):1192-1195. doi: 10.1589/jpts.29.1192. Epub 2017 Jul 15.
[Purpose] The purpose of this study was to determine whether collagen fibers cause a difference in a contracture resulting from a combination of joint fixation and hindlimb unloading as compared to joint fixation only. [Subjects and Methods] The subjects of this study were 21 female Wistar rats divided into 4 groups as follows: Control Group (CON, n=7); Joint Fixation Group (JF, n=7), Hindlimb Unloading Group (HU, n=7), Joint Fixation Plus Hindlimb Unloading Group (JF+HU, n=7). This study was conducted for 1-week. Ankle joint range of motion and positive areas of collagen using fluorescent stain were analyzed. [Results] Ankle joint range of motion in JF + HU showed an increase compared to that of JF. Positive areas of Type I collagen in JF+HU showed an increase as compared with that of JF. [Conclusion] The results of this study suggested that the difference in a contracture caused by only joint immobilization and by a combination of joint immobilization and hindlimb unloading were significantly associated with Type I collagen.
[目的]本研究旨在确定与单纯关节固定相比，胶原纤维是否会导致关节固定与后肢卸载联合作用所引起的挛缩差异。[对象与方法]本研究对象为21只雌性Wistar大鼠，分为以下4组：对照组（CON，n = 7）；关节固定组（JF，n = 7），后肢卸载组（HU，n = 7），关节固定加后肢卸载组（JF + HU，n = 7）。本研究持续1周。分析踝关节活动范围以及使用荧光染色法检测的胶原阳性面积。[结果]与JF组相比，JF + HU组的踝关节活动范围有所增加。与JF组相比，JF + HU组I型胶原的阳性面积有所增加。[结论]本研究结果表明，单纯关节固定与关节固定和后肢卸载联合作用所引起的挛缩差异与I型胶原显著相关。
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