• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

通过将同步加速器小角 X 射线散射与微流控相结合，在将 citrem 纳米颗粒暴露于含有大豆磷脂的乙醇溶液中时直接监测脂质转移。

Direct monitoring of lipid transfer on exposure of citrem nanoparticles to an ethanol solution containing soybean phospholipids by combining synchrotron SAXS with microfluidics.

机构信息

Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen Ø, Denmark.

出版信息

Analyst. 2017 Aug 21;142(17):3118-3126. doi: 10.1039/c7an00860k.

DOI:10.1039/c7an00860k
PMID:28744529
Abstract

Lipid exchange among citrem nanoparticles and an ethanol micellar solution containing soy phosphatidylcholine was investigated in situ by coupling small angle X-ray scattering with a microfluidic device. The produced soy phosphatidylcholine/citrem nanoparticles have great potential in the development of hemocompatible nanocarriers for drug delivery.

摘要

采用小角 X 射线散射与微流控装置相结合的方法，在原位研究了 citrem 纳米颗粒与含有大豆卵磷脂的乙醇胶束溶液之间的脂质交换。所制备的大豆卵磷脂/citrem 纳米颗粒在开发用于药物输送的抗凝血纳米载体方面具有很大的潜力。

相似文献

1
Direct monitoring of lipid transfer on exposure of citrem nanoparticles to an ethanol solution containing soybean phospholipids by combining synchrotron SAXS with microfluidics.通过将同步加速器小角 X 射线散射与微流控相结合，在将 citrem 纳米颗粒暴露于含有大豆磷脂的乙醇溶液中时直接监测脂质转移。
Analyst. 2017 Aug 21;142(17):3118-3126. doi: 10.1039/c7an00860k.
2
Temperature triggering of kinetically trapped self-assemblies in citrem-phospholipid nanoparticles.温度触发柠檬酸根 - 磷脂纳米粒中动力学捕获的自组装体。
Chem Phys Lipids. 2018 Nov;216:30-38. doi: 10.1016/j.chemphyslip.2018.09.003. Epub 2018 Sep 14.
3
Advances in microfluidic synthesis and coupling with synchrotron SAXS for continuous production and real-time structural characterization of nano-self-assemblies.微流体制备技术的进展及其与同步辐射小角 X 射线散射（SAXS）的联用，用于纳米自组装体的连续生产和实时结构表征。
Colloids Surf B Biointerfaces. 2021 May;201:111633. doi: 10.1016/j.colsurfb.2021.111633. Epub 2021 Feb 18.
4
Application of small-angle X-ray scattering to the characterization and quantification of the drug transport nanosystem based on the soybean phosphatidylcholine.小角X射线散射在基于大豆磷脂酰胆碱的药物转运纳米系统的表征和定量分析中的应用。
J Pharm Biomed Anal. 2015 Oct 10;114:288-91. doi: 10.1016/j.jpba.2015.05.034. Epub 2015 Jun 1.
5
Comprehensive characterization of nanostructured lipid carriers using laboratory and synchrotron X-ray scattering and diffraction.使用实验室和同步辐射 X 射线散射和衍射对纳米结构脂质载体进行综合表征。
Eur J Pharm Biopharm. 2019 Jun;139:153-160. doi: 10.1016/j.ejpb.2019.03.017. Epub 2019 Mar 21.
6
Continuous Microfluidic Production of Citrem-Phosphatidylcholine Nano-Self-Assemblies for Thymoquinone Delivery.用于递送百里醌的柠檬酸-磷脂酰胆碱纳米自组装体的连续微流体制备
Nanomaterials (Basel). 2021 Jun 7;11(6):1510. doi: 10.3390/nano11061510.
7
Microfluidic Nanomaterial Synthesis and In Situ SAXS, WAXS, or SANS Characterization: Manipulation of Size Characteristics and Online Elucidation of Dynamic Structural Transitions.微流控纳米材料合成及原位小角 X 射线散射（SAXS）、广角 X 射线散射（WAXS）或小角中子散射（SANS）表征：尺寸特征的调控及动态结构转变的在线阐明。
Molecules. 2022 Jul 19;27(14):4602. doi: 10.3390/molecules27144602.
8
Citrem-phosphatidylcholine nano-self-assemblies: solubilization of bupivacaine and its role in triggering a colloidal transition from vesicles to cubosomes and hexosomes.柠檬酸磷脂酰胆碱纳米自组装体：布比卡因的增溶作用及其在触发从囊泡到立方相和六方相的胶体转变中的作用。
Phys Chem Chem Phys. 2019 Jul 10;21(27):15142-15150. doi: 10.1039/c9cp01878f.
9
Structural effects of the dispersing agent polysorbate 80 on liquid crystalline nanoparticles of soy phosphatidylcholine and glycerol dioleate.分散剂聚山梨酯 80 对大豆卵磷脂和甘油二油酸酯液晶纳米粒的结构影响。
Soft Matter. 2015 Feb 14;11(6):1140-50. doi: 10.1039/c4sm02296c.
10
Coencapsulation of Gemcitabine and Thymoquinone in Citrem-Phosphatidylcholine Hexosome Nanocarriers Improves In Vitro Cellular Uptake in Breast Cancer Cells.将吉西他滨和姜黄素共同包封于柠檬酸磷脂酰胆碱六方脂质体纳米载体中可提高乳腺癌细胞的体外细胞摄取率。
Mol Pharm. 2023 Sep 4;20(9):4611-4628. doi: 10.1021/acs.molpharmaceut.3c00333. Epub 2023 Aug 16.

引用本文的文献

1
Recent advances in structural characterization of biomacromolecules in foods small-angle X-ray scattering.食品中生物大分子结构表征的最新进展——小角X射线散射
Front Nutr. 2022 Nov 17;9:1039762. doi: 10.3389/fnut.2022.1039762. eCollection 2022.
2
Microfluidic Nanomaterial Synthesis and In Situ SAXS, WAXS, or SANS Characterization: Manipulation of Size Characteristics and Online Elucidation of Dynamic Structural Transitions.微流控纳米材料合成及原位小角 X 射线散射（SAXS）、广角 X 射线散射（WAXS）或小角中子散射（SANS）表征：尺寸特征的调控及动态结构转变的在线阐明。
Molecules. 2022 Jul 19;27(14):4602. doi: 10.3390/molecules27144602.
3
Continuous Microfluidic Production of Citrem-Phosphatidylcholine Nano-Self-Assemblies for Thymoquinone Delivery.
用于递送百里醌的柠檬酸-磷脂酰胆碱纳米自组装体的连续微流体制备
Nanomaterials (Basel). 2021 Jun 7;11(6):1510. doi: 10.3390/nano11061510.
4
Recent advances in drug delivery applications of cubosomes, hexosomes, and solid lipid nanoparticles.立方液晶纳米粒、六方液晶纳米粒和固体脂质纳米粒在药物递送应用方面的最新进展。
Acta Pharm Sin B. 2021 Apr;11(4):871-885. doi: 10.1016/j.apsb.2021.02.013. Epub 2021 Feb 24.
5
Self-Assembled Nanostructured Lipid Systems: Is There a Link between Structure and Cytotoxicity?自组装纳米结构脂质体系：结构与细胞毒性之间存在关联吗？
Adv Sci (Weinh). 2018 Nov 12;6(3):1801223. doi: 10.1002/advs.201801223. eCollection 2019 Feb 6.