Kleshchenko Yu E, Zhigunova A V, Dalin M V, Melnikov V
Department of Microbiology and Virology, Medical Institute, Peopleэs Friendship University of Russia, Moscow, Russia.
Laboratory of Molecular Biology, School of Medicine, University of Colima, Colima, Mexico.
Bull Exp Biol Med. 2017 Jul;163(3):361-364. doi: 10.1007/s10517-017-3804-0. Epub 2017 Jul 25.
Four peptide sequences characterized by high content of hydrophobic, charged, and polar amino acids were obtained from 23 clones of M13 phage. Peptides P2 and P4 exhibited highest binding affinity for immobilized trypomastigotes. The inhibitory effects of peptides seemed to be due to blockade of certain epitopes on T. cruzi surface proteins responsible for interactions with the respective receptors of host cells.
从23个M13噬菌体克隆中获得了4个以高含量疏水、带电荷和极性氨基酸为特征的肽序列。肽P2和P4对固定化的锥鞭毛体表现出最高的结合亲和力。肽的抑制作用似乎是由于阻断了克氏锥虫表面蛋白上某些负责与宿主细胞各自受体相互作用的表位。
