载体介导的药物在肿瘤组织中分布的复杂效应受肿瘤微环境的影响。
Complex effects of tumor microenvironment on the tumor disposition of carrier-mediated agents.
机构信息
Division of Pharmacotherapy & Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
出版信息
Nanomedicine (Lond). 2017 Aug;12(16):2021-2042. doi: 10.2217/nnm-2017-0101. Epub 2017 Jul 26.
Abstract
Major advances in carrier-mediated agents, including nanoparticle, conjugates and antibody-drug conjugates, have created revolutionary drug delivery systems in cancer over the past two decades. While these agents provide several advantages, such as greater duration of exposure and solubility, compared with their small-molecule counterparts, there is substantial variability in delivery of these agents to tissues and especially tumors. This review provides an overview of tumor microenvironment factors that affect the pharmacokinetics and pharmacodynamics of carrier-mediated agents observed in preclinical models and patients.
摘要
在过去的二十年中，载体介导的药物输送系统（包括纳米粒子、缀合物和抗体药物偶联物）在癌症治疗方面取得了重大进展。尽管与小分子药物相比，这些药物具有更大的暴露时间和溶解度等优势，但它们在向组织（特别是肿瘤）输送方面仍存在较大的变异性。本文综述了肿瘤微环境因素对临床前模型和患者中观察到的载体介导药物的药代动力学和药效学的影响。
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