Department of Clinical Pharmacy, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, 211198, Jiangsu Province, People's Republic of China.
Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing, 211198, China.
AAPS PharmSciTech. 2020 May 14;21(4):132. doi: 10.1208/s12249-020-01691-3.
The superiority of nanomedicine over conventional medicines in the treatment of cancer has gained immediate recognition worldwide. As traditional cancer therapies are nonspecific and detrimental to healthy cells, the ability of nanomedicine to release drugs to target tumor cells specifically instead of healthy cells has brought new hope to cancer patients. This review focuses on the effects of various factors of nanoparticles such as transport, concentration in cells, tumor microenvironment, interaction with protein, penetration, uptake by tumor cells, cancer cell mutations, and intracellular trafficking of the nanoparticle. Besides the history of nanomedicine, future perspectives of nanomedicines are also explored in this text.
纳米医学在癌症治疗方面优于传统药物，这一优势已在全球范围内得到认可。由于传统癌症疗法是非特异性的，会对健康细胞造成损害，因此纳米医学能够将药物释放到特定的肿瘤细胞而不是健康细胞上，这为癌症患者带来了新的希望。本文重点介绍了纳米颗粒的各种因素的影响，如运输、在细胞中的浓度、肿瘤微环境、与蛋白质的相互作用、穿透性、肿瘤细胞的摄取、癌细胞突变以及纳米颗粒的细胞内运输。除了纳米医学的历史，本文还探讨了纳米医学的未来展望。
