Wunderink H F, Vlasveld I N, Knol M J, van der Ende A, van Essen E H R, Kuijper E J
Leids Universitair Medisch Centrum, Leiden.
Ned Tijdschr Geneeskd. 2017;161:D1456.
Meningococcal disease usually presents as meningitis and/or septicaemia, but can also present as pneumonia or arthritis. Since 2000, a worldwide increase in meningococcal disease is reported which is caused by a new virulent clone of serogroup W (MenW:cc11). This subtype is more likely to give an atypical clinical presentation and results in high mortality rates.
A 68-year-old woman with polymyalgia rheumatica, managed with prednisone, developed an acute gastrointestinal syndrome of nausea, diarrhoea, vomiting, fever and chills. She presented at the Emergency Department and was admitted to intensive care for septic shock. Blood cultures revealed MenW:cc11 infection. She received antibiotic treatment and left the hospital in good condition 8 days after admission.
MenW:cc11 is associated with gastrointestinal symptoms and sepsis. Recognition of this atypical clinical presentation is important for a timely and adequate treatment and for antibiotic prophylaxis of family members and close contacts.
脑膜炎球菌病通常表现为脑膜炎和/或败血症,但也可表现为肺炎或关节炎。自2000年以来,据报道全球脑膜炎球菌病有所增加,这是由血清群W的一种新的毒性克隆株(MenW:cc11)引起的。这种亚型更有可能出现非典型临床表现,并导致高死亡率。
一名68岁患有风湿性多肌痛的女性,正在使用泼尼松进行治疗,出现了恶心、腹泻、呕吐、发热和寒战的急性胃肠综合征。她到急诊科就诊,并因感染性休克被收入重症监护病房。血培养显示为MenW:cc11感染。她接受了抗生素治疗,入院8天后康复出院。
MenW:cc11与胃肠道症状和败血症有关。认识这种非典型临床表现对于及时、充分的治疗以及对家庭成员和密切接触者进行抗生素预防非常重要。