Johann Anna F, Hertenstein Elisabeth, Kyle Simon D, Baglioni Chiara, Feige Bernd, Nissen Christoph, McGinness Alastair J, Riemann Dieter, Spiegelhalder Kai
Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Medical Psychology and Medical Sociology, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
PLoS One. 2017 Jul 26;12(7):e0180339. doi: 10.1371/journal.pone.0180339. eCollection 2017.
To replicate the association between insomnia with objective short sleep duration and hypertension, type 2 diabetes and duration of insomnia.
Retrospective case-control study.
Department of Psychiatry and Psychotherapy, Medical Center-University of Freiburg.
328 patients with primary insomnia classified according to DSM-IV criteria (125 males, 203 females, 44.3 ± 12.2 years).
N/A.
All participants were investigated using polysomnography, blood pressure measurements, and fasting routine laboratory.
Insomnia patients with short sleep duration (< 6 hours) in the first night of laboratory sleep presented with a longer duration of insomnia compared to those with normal sleep duration (≥ 6 hours) in the first night of laboratory sleep. Insomnia patients who were categorised as short sleepers in either night were not more likely to suffer from hypertension (systolic blood pressure of ≥ 140 mm Hg, diastolic blood pressure of ≥ 90 mm Hg, or a previously established diagnosis). Data analysis showed that insomnia patients with objective short sleep duration were not more likely to suffer from type 2 diabetes (fasting plasma glucose level of ≥ 126 mg/dl, or a previously established diagnosis). However, the diabetes analysis was only based on a very small number of diabetes cases. As a new finding, insomnia patients who were categorised as short sleepers in either night presented with increases in liver enzyme levels.
The finding on insomnia duration supports the concept of two distinct sub-groups of insomnia, namely insomnia with, and without, objectively determined short sleep duration. However, our data challenges previous findings that insomnia patients with short sleep duration are more likely to suffer from hypertension.
重复失眠与客观短睡眠时间、高血压、2型糖尿病及失眠持续时间之间的关联。
回顾性病例对照研究。
弗莱堡大学医学中心精神科与心理治疗科。
328例根据《精神疾病诊断与统计手册》第四版标准分类的原发性失眠患者（男性125例，女性203例，年龄44.3±12.2岁）。
无。
所有参与者均接受多导睡眠图检查、血压测量及空腹常规实验室检查。
实验室睡眠第一晚睡眠持续时间短（<6小时）的失眠患者，与实验室睡眠第一晚睡眠持续时间正常（≥6小时）的患者相比，失眠持续时间更长。在任何一晚被归类为短睡眠者的失眠患者患高血压（收缩压≥140mmHg，舒张压≥90mmHg，或既往确诊）的可能性并不更高。数据分析显示，客观短睡眠时间的失眠患者患2型糖尿病（空腹血糖水平≥126mg/dl，或既往确诊）的可能性并不更高。然而，糖尿病分析仅基于极少数糖尿病病例。作为一项新发现，在任何一晚被归类为短睡眠者的失眠患者肝酶水平升高。
关于失眠持续时间的研究结果支持将失眠分为两个不同亚组的概念，即客观睡眠时间短和不短的失眠。然而，我们的数据对之前关于短睡眠时间的失眠患者更易患高血压的研究结果提出了挑战。
