张力钌（II）配合物的光毒性：是金属配合物还是解离配体？
Phototoxicity of strained Ru(ii) complexes: is it the metal complex or the dissociating ligand?
作者信息
Azar Daniel F, Audi Hassib, Farhat Stephanie, El-Sibai Mirvat, Abi-Habib Ralph J, Khnayzer Rony S
机构信息
Department of Natural Sciences, Lebanese American University, Chouran, Beirut 1102-2801, Lebanon.
出版信息
Dalton Trans. 2017 Sep 12;46(35):11529-11532. doi: 10.1039/c7dt02255g.
A photochemically dissociating ligand in Ru(bpy)(dmphen)Cl [bpy = 2,2'-bipyridine; dmphen = 2,9-dimethyl-1,10-phenanthroline] was found to be more cytotoxic on the ML-2 Acute Myeloid Leukemia cell line than Ru(bpy)(HO) and prototypical cisplatin. Our findings illustrate the potential potency of diimine ligands in photoactivatable Ru(ii) complexes.
已发现Ru(bpy)(dmphen)Cl [bpy = 2,2'-联吡啶；dmphen = 2,9-二甲基-1,10-菲咯啉]中的一种光化学解离配体对ML-2急性髓性白血病细胞系的细胞毒性比Ru(bpy)(HO)和典型的顺铂更强。我们的研究结果说明了二亚胺配体在可光活化的Ru(ii)配合物中的潜在效力。
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