Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, 135 Dauer Dr, Chapel Hill, NC, 27599, USA.
University of North Carolina at Chapel Hill Center for Intellectual and Developmental Disabilities, 101 Renee Lynne Ct, Carrboro, NC, 27510, USA.
J Autism Dev Disord. 2017 Oct;47(10):3253-3266. doi: 10.1007/s10803-017-3248-4.
Autism spectrum disorder (ASD) diagnosis relies on parent-reported and clinician-observed instruments. Sometimes, results between these instruments disagree. The broader autism phenotype (BAP) in parent-reporters may be associated with discordance. Study to Explore Early Development data (N = 712) were used to address whether mothers with BAP and children with ASD or non-ASD developmental disabilities were more likely than mothers without BAP to 'over-' or 'under-report' child ASD on ASD screeners or interviews compared with clinician observation or overall impression. Maternal BAP was associated with a child meeting thresholds on a maternal-reported screener or maternal interview when clinician ASD instruments or impressions did not (risk ratios: 1.30 to 2.85). Evidence suggests acknowledging and accounting for reporting discordances may be important when diagnosing ASD.
自闭症谱系障碍 (ASD) 的诊断依赖于家长报告和临床医生观察的工具。有时，这些工具的结果不一致。在报告者家长中广泛存在的自闭症表型 (BAP) 可能与这种不一致有关。使用探索早期发育数据（N=712）来解决是否具有 BAP 的母亲和患有 ASD 或非 ASD 发育障碍的儿童比没有 BAP 的母亲更有可能在 ASD 筛查或访谈中“过度”或“不足”报告孩子的 ASD，而与临床医生观察或总体印象相比。当临床医生的 ASD 工具或印象没有达到标准时，母亲的 BAP 与孩子在母亲报告的筛查或母亲访谈中达到标准有关（风险比：1.30 至 2.85）。有证据表明，在诊断 ASD 时，承认和考虑报告差异可能很重要。
