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用于乳腺癌生物医学研究的改良无动物模型的开发进展。

Advances in the development of improved animal-free models for use in breast cancer biomedical research.

作者信息

Roberts Sophie, Speirs Valerie

机构信息

Leeds Institute of Cancer & Pathology, University of Leeds, St James's University Hospital, Wellcome Trust Brenner Building, Leeds, LS9 7TF, UK.

出版信息

Biophys Rev. 2017 Aug;9(4):321-327. doi: 10.1007/s12551-017-0276-4. Epub 2017 Jul 26.

DOI:10.1007/s12551-017-0276-4
PMID:28748520
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5578919/
Abstract

Through translational research, the outcomes for women (and men) diagnosed with breast cancer have improved significantly, with now over 80% of women surviving for at least 5 years post-diagnosis. Much of this success has been translated from the bench to the bedside using laboratory models. Here, we outline the types of laboratory models that have helped achieve this and discuss new approaches as we move towards animal-free disease modelling.

摘要

通过转化研究，被诊断患有乳腺癌的女性（以及男性）的治疗结果有了显著改善，目前超过80%的女性在确诊后至少存活了5年。这项成功很大程度上是利用实验室模型从实验台转化到了临床。在此，我们概述了有助于实现这一目标的实验室模型类型，并讨论了在迈向无动物疾病建模过程中的新方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12c9/5578919/0c32747405d6/12551_2017_276_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12c9/5578919/e7238376f1bd/12551_2017_276_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12c9/5578919/b512a48c4de2/12551_2017_276_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12c9/5578919/0c32747405d6/12551_2017_276_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12c9/5578919/e7238376f1bd/12551_2017_276_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12c9/5578919/b512a48c4de2/12551_2017_276_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12c9/5578919/0c32747405d6/12551_2017_276_Fig3_HTML.jpg

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