White Robert A, Silvey Michael, Logsdon Derek P
Department of Biochemistry, Kansas City University of Medicine and Biosciences, USA.
Mo Med. 2012 May-Jun;109(3):195-8.
Transgenic mice represent a unique opportunity in biomedical research to discover the genes underlying disease and understand how manipulating the function of single genes and proteins alters physiology in a whole animal system. These advances in biomedical research may accelerate the time between when basic discoveries are made and when the research can be 'translated', that is, when the research will positively impact the lives of patients. The purpose of this article is to present some examples of promising mouse models of human diseases.
转基因小鼠在生物医学研究中提供了一个独特的契机，可用于发现引发疾病的基因，并了解操纵单个基因和蛋白质的功能如何在整个动物系统中改变生理学特性。生物医学研究中的这些进展可能会缩短从做出基础发现到研究能够“转化”（即研究将对患者生活产生积极影响）之间的时间。本文旨在列举一些有前景的人类疾病小鼠模型实例。
