Upper Gastrointestinal Surgery, Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Jockey Club School of Public Health and Primary Care, the Chinese University of Hong Kong, Hong Kong, SAR, China.
Int J Cancer. 2017 Nov 15;141(10):1981-1986. doi: 10.1002/ijc.30908. Epub 2017 Aug 7.
Lung cancer risk and tumor characteristics differ between sexes. Estrogen has been suggested to counteract lung cancer development. We aimed to test the hypothesis that digitalis use decreases lung cancer risk due to its estrogenic and other anticancer properties in men. This was a nationwide Swedish population-based cohort study between July 1, 2005 and December 31, 2013. Data on the use of digitalis and organic nitrates in all male individuals were derived from the Swedish Prescribed Drug Registry. New lung cancer diagnoses among cohort participants were identified from the Swedish Cancer Registry. Cox proportional hazards regression was employed to estimate hazard ratios (HRs) with 95% confidence intervals (CIs) of lung cancer in digitalis users (exposed participants) compared to users of organic nitrates without digitalis medication (unexposed participants). The study cohort contained 74,437 digitalis users and 297,301 organic nitrates users. Long-term use (≥2 years) of digitalis was associated with decreased HRs of total lung cancer (HR 0.55, 95% CI 0.39-0.79) and squamous cell carcinoma (HR 0.40, 95% CI 0.19-0.87). This large and population-based study suggests decreased risks of lung cancer overall and squamous cell carcinoma associated with long-term use of digitalis in men.
肺癌风险和肿瘤特征因性别而异。雌激素被认为可以对抗肺癌的发生。我们旨在检验以下假设，即洋地黄的使用由于其雌激素和其他抗癌特性，可以降低男性的肺癌风险。这是一项在 2005 年 7 月 1 日至 2013 年 12 月 31 日期间进行的全国性瑞典人群队列研究。所有男性个体使用洋地黄和有机硝酸盐的数据均来自瑞典处方药物登记处。队列参与者中新诊断的肺癌病例来自瑞典癌症登记处。采用 Cox 比例风险回归估计洋地黄使用者（暴露组）与未使用洋地黄药物的有机硝酸盐使用者（未暴露组）肺癌的风险比（HR）及其 95%置信区间（CI）。该研究队列包含 74437 名洋地黄使用者和 297301 名有机硝酸盐使用者。长期（≥2 年）使用洋地黄与总肺癌（HR 0.55，95%CI 0.39-0.79）和鳞状细胞癌（HR 0.40，95%CI 0.19-0.87）的 HR 降低相关。这项大型的基于人群的研究表明，长期使用洋地黄与男性的总肺癌和鳞状细胞癌风险降低有关。
