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重金属对大鼠离体小肠主动转运的抑制作用。与其他离子的相互作用。

Heavy metal-induced inhibition of active transport in the rat small intestine in vitro. Interaction with other ions.

作者信息

Iturri S J, Peña A

出版信息

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1986;84(2):363-8. doi: 10.1016/0742-8413(86)90106-4.

DOI:10.1016/0742-8413(86)90106-4
PMID:2874953
Abstract

The effect of Hg2+, Cd2+ and Pb2+ on the intestinal transport of D-glucose and L-tyrosine was studied in everted sacs of small intestine. Hg2+, Cd2+ and Pb2+ (10(-5) and 10(-4)) singly or in combination inhibit the active transport of D-glucose (10 mM) and L-tyrosine (2 mM) in rat and pigeon small intestine. The presence of other ions (Mg2+, Zn2+ and SeO3(2)) diminishes the toxic effect of heavy metal ions, rendering them less effective.

摘要

研究了Hg2+、Cd2+和Pb2+对小肠外翻囊泡中D-葡萄糖和L-酪氨酸肠道转运的影响。Hg2+、Cd2+和Pb2+(10^(-5)和10^(-4))单独或联合使用时,会抑制大鼠和鸽子小肠中D-葡萄糖(10 mM)和L-酪氨酸(2 mM)的主动转运。其他离子(Mg2+、Zn2+和SeO3^(2))的存在会减弱重金属离子的毒性作用,使其效果降低。

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Comp Biochem Physiol C Comp Pharmacol Toxicol. 1986;84(2):363-8. doi: 10.1016/0742-8413(86)90106-4.
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