García-García Emilio, López-González Mercedes, Cabello-Laureano Rosa, Navarro-González Elena
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J Pediatr Endocrinol Metab. 2017 Aug 28;30(8):847-850. doi: 10.1515/jpem-2016-0368.
Multinodular goiter (MG) is very common in adults. MG may occur in children in some exceptional circumstances. The objective of this study was to examine two cases of MG in children who relapsed soon after surgery and to discuss the treatment options in pediatric ages.
Two girls consulted for euthyroid colloid goiter, uninodular goiter and bilateral MG. They were intervened by hemithyroidectomy and total thyroidectomy, respectively, due to the existence of local symptoms.
Goiters reappeared 3 years after intervention in both cases. They already appeared as bilaterally MG, and patients underwent a total thyroidectomy, in one case after 1 year of treatment with levothyroxine (LT4).
MG treatment remains controversial. There is an increasing trend to a more radical surgery decreasing recurrence risk. Treatment with LT4 may be tested but it is rarely effective. Regardless of the therapeutic option, these children should be followed up and they should know about the possibility of goiter regeneration and the need for reintervention.
多结节性甲状腺肿(MG)在成年人中非常常见。在某些特殊情况下,MG也可能发生于儿童。本研究的目的是检查两例儿童MG患者,他们在手术后不久复发,并讨论儿童期的治疗选择。
两名女孩因甲状腺功能正常的胶样甲状腺肿、单结节性甲状腺肿和双侧MG前来就诊。由于存在局部症状,她们分别接受了半甲状腺切除术和全甲状腺切除术。
两例患者在干预3年后甲状腺肿均复发。复发时已表现为双侧MG,其中一例在接受左甲状腺素(LT4)治疗1年后接受了全甲状腺切除术。
MG的治疗仍存在争议。采用更激进的手术以降低复发风险的趋势正在增加。可以尝试使用LT4进行治疗,但很少有效。无论选择何种治疗方法,都应对这些儿童进行随访,并且他们应该了解甲状腺肿再生的可能性以及再次干预的必要性。