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Phosphatidylserine and phorbol myristate acetate stimulation of human lymphocyte guanylate cyclase.

作者信息

Coffey R G

出版信息

Int J Biochem. 1986;18(7):665-70. doi: 10.1016/0020-711x(86)90298-3.

DOI:10.1016/0020-711x(86)90298-3
PMID:2875002
Abstract

Guanylate cyclase activities of human lymphocyte membrane and cytosol preparations are stimulated up to three-fold by the direct addition of phosphatidylserine. Phorbol 12-myristate 13-acetate (PMA) greatly augments the effect of phosphatidylserine, but has only a small effect when added alone. Stimulation involves an increase in Vmax, with no change in Km. Inhibitor studies suggest that stimulation may be mediated by protein kinase C, but not by phospholipase or lipoxygenase.

摘要

相似文献

1
Phosphatidylserine and phorbol myristate acetate stimulation of human lymphocyte guanylate cyclase.
Int J Biochem. 1986;18(7):665-70. doi: 10.1016/0020-711x(86)90298-3.
2
Phorbol myristate acetate stimulation of lymphocyte guanylate cyclase.佛波醇肉豆蔻酸酯乙酸盐对淋巴细胞鸟苷酸环化酶的刺激作用
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3
Phorbol myristate acetate stimulation of lymphocyte guanylate cyclase and cyclic guanosine 3':5'-monophosphate phosphodiesterase and reduction of adenylate cyclase.佛波醇肉豆蔻酸酯乙酸盐对淋巴细胞鸟苷酸环化酶和环磷酸鸟苷3':5'-单磷酸磷酸二酯酶的刺激作用以及对腺苷酸环化酶的抑制作用。
Cancer Res. 1983 Jan;43(1):150-8.
4
Ca2+ and phorbol ester activation of protein kinase C at intracellular Ca2+ concentrations and the effect of TMB-8.细胞内钙离子浓度下蛋白激酶C的钙离子和佛波酯激活以及TMB-8的作用。
Biochim Biophys Acta. 1986 Jun 3;882(1):57-62. doi: 10.1016/0304-4165(86)90055-3.
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Activation of myelin protein kinase by diacylglycerol and 4 beta-phorbol 12-myristate 13-acetate.二酰甘油和4β-佛波醇12-肉豆蔻酸酯13-乙酸酯对髓鞘蛋白激酶的激活作用。
J Neurochem. 1986 May;46(5):1655-7. doi: 10.1111/j.1471-4159.1986.tb01791.x.
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Inhibition of beta-adrenergic stimulation of lymphocyte adenylate cyclase by phorbol myristate acetate is mediated by activated macrophages.
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Phorbol myristate acetate mediates redistribution of protein kinase C in human neutrophils: potential role in the activation of the respiratory burst enzyme.佛波醇肉豆蔻酸酯乙酸盐介导蛋白激酶C在人中性粒细胞中的重新分布：在呼吸爆发酶激活中的潜在作用。
J Immunol. 1985 Sep;135(3):2057-62.
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Parathyroid hormone causes translocation of protein kinase-C from cytosol to membranes in rat osteosarcoma cells.甲状旁腺激素可导致大鼠骨肉瘤细胞中的蛋白激酶-C从胞质溶胶转移至细胞膜。
Endocrinology. 1989 Mar;124(3):1107-13. doi: 10.1210/endo-124-3-1107.

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