硫利达嗪亚砜和N-氧化物非对映异构体的色谱分离：鉴定为大鼠体内的代谢物。

Chromatographic separation of thioridazine sulphoxide and N-oxide diastereoisomers: identification as metabolites in the rat.

作者信息

Watkins G M, Whelpton R, Buckley D G, Curry S H

出版信息

J Pharm Pharmacol. 1986 Jul;38(7):506-9. doi: 10.1111/j.2042-7158.1986.tb04624.x.

DOI:10.1111/j.2042-7158.1986.tb04624.x

Abstract

(+/-)-Thioridazine and (+/-)-desmethylthioridazine have been oxidized to produce a number of chiral sulphoxide and amine oxide compounds. Diastereoisomeric isomers were separated by thin-layer and high performance liquid chromatography. Thioridazine-5-sulphoxide, N-desmethylthioridazine-5-sulphoxide and thioridazine-N-oxide diastereoisomers were found to be thioridazine metabolites following dosing in rats or after in-vitro incubation with rat liver homogenate.

摘要

（±）-硫利达嗪和（±）-去甲基硫利达嗪已被氧化，生成了多种手性亚砜和氧化胺化合物。非对映异构体通过薄层色谱法和高效液相色谱法进行分离。在大鼠给药后或与大鼠肝脏匀浆进行体外孵育后，发现硫利达嗪-5-亚砜、N-去甲基硫利达嗪-5-亚砜和硫利达嗪-N-氧化物非对映异构体是硫利达嗪的代谢产物。