去甲肾上腺素前体L-苏式-3,4-二羟基苯丝氨酸对大鼠和小鼠的利尿作用。

Diuretic effect of L-threo-3,4-dihydroxyphenylserine, a noradrenaline precursor, in rats and mice.

作者信息

Katsube J, Kato T, Katsuyama M, Maeda Y, Nishikawa S, Nakamura M

出版信息

J Pharm Pharmacol. 1986 Jul;38(7):533-4. doi: 10.1111/j.2042-7158.1986.tb04631.x.

DOI:10.1111/j.2042-7158.1986.tb04631.x

Abstract

L-Threo-DOPS, a noradrenaline (NA) precursor, produced a dose-dependent increase in the volume of urine in mice and rats. It also increased the total output of sodium and chloride ions, but not the excretion of potassium ion. Treatment with peripheral decarboxylase inhibitors antagonized not only the diuretic action, but also the increase in the concentration of kidney NA produced by L-threo-DOPS. These results suggest that the diuretic action of L-threo-DOPS might not be due to its direct action, but largely to NA formed by its decarboxylation in the kidney.

摘要

L-苏糖酸多巴胺（L-Threo-DOPS），一种去甲肾上腺素（NA）前体，可使小鼠和大鼠的尿量呈剂量依赖性增加。它还增加了钠和氯离子的总排出量，但不增加钾离子的排泄量。用外周脱羧酶抑制剂处理不仅拮抗了利尿作用，还拮抗了L-苏糖酸多巴胺引起的肾脏NA浓度升高。这些结果表明，L-苏糖酸多巴胺的利尿作用可能不是由于其直接作用，而是很大程度上归因于其在肾脏中脱羧形成的NA。