靶向癌症中的自噬。
Targeting autophagy in cancer.
作者信息
Levy Jean M Mulcahy, Towers Christina G, Thorburn Andrew
机构信息
Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado 80045, USA.
Morgan Adams Foundation Pediatric Brain Tumor Research Program, Children's Hospital Colorado, Aurora, Colorado 80045, USA.
出版信息
Nat Rev Cancer. 2017 Sep;17(9):528-542. doi: 10.1038/nrc.2017.53. Epub 2017 Jul 28.
Abstract
Autophagy is a mechanism by which cellular material is delivered to lysosomes for degradation, leading to the basal turnover of cell components and providing energy and macromolecular precursors. Autophagy has opposing, context-dependent roles in cancer, and interventions to both stimulate and inhibit autophagy have been proposed as cancer therapies. This has led to the therapeutic targeting of autophagy in cancer to be sometimes viewed as controversial. In this Review, we suggest a way forwards for the effective targeting of autophagy by understanding the context-dependent roles of autophagy and by capitalizing on modern approaches to clinical trial design.
摘要
自噬是一种将细胞物质输送到溶酶体进行降解的机制，可导致细胞成分的基础更新，并提供能量和大分子前体。自噬在癌症中具有相反的、取决于具体情况的作用，刺激和抑制自噬的干预措施均已被提议作为癌症治疗方法。这使得癌症中自噬的治疗靶点有时被视为具有争议性。在本综述中，我们通过理解自噬取决于具体情况的作用并利用现代临床试验设计方法，提出了有效靶向自噬的前进方向。
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