采用颊黏膜进行两阶段尿道成形术治疗46,XX核型男性的阴茎阴囊型尿道下裂重建术

Two-Stage Urethroplasty with Buccal Mucosa for Penoscrotal Hypospadias Reconstruction in a Male with a 46,XX Karyotype.

作者信息

D'hulst Pieter, Darras Jochen, Joniau Steven, Mattelaer Pieter, Winne Linsey, Ponette Diederik

机构信息

Dept. of Urology Az Damiaan Oostende, Gouwelozestraat 100, 8400 Oostende, Belgium.

Dept. of Urology UZ Leuven, Herestraat 49, 3000 Leuven, Belgium.

出版信息

Urol Case Rep. 2017 Jul 18;14:45-47. doi: 10.1016/j.eucr.2017.06.016. eCollection 2017 Sep.

DOI:10.1016/j.eucr.2017.06.016

PMID:28752067

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5522374/

Abstract

We present a case regarding a 32-year old African male with penoscrotal hypospadias, left cryptorchidism and a left inguinal hernia. There were moderate masculinization characteristics. He underwent a Lichtenstein hernia repair with perioperative biopsies of the left inguinal testis and epididymis. Microscopic examination showed a Sertoli-only left testis with Leydig-cell hyperplasia and the left epididymis consisted of ovarian tissue with corpora albicantia and maturing follicles. Endocrinological evaluation showed a sex-determining region Y (SRY) negative 46,XX karyotype. We successfully performed a two-stage urethroplasty with buccal mucosa graft to reconstruct his penoscrotal hypospadias.

摘要

我们报告一例32岁的非洲男性病例，其患有阴茎阴囊型尿道下裂、左侧隐睾和左侧腹股沟疝。存在中度男性化特征。他接受了利chtenstein疝修补术，并在围手术期对左侧腹股沟睾丸和附睾进行了活检。显微镜检查显示左侧睾丸仅为支持细胞，伴有睾丸间质细胞增生，左侧附睾由含有白体和成熟卵泡的卵巢组织组成。内分泌评估显示性别决定区Y（SRY）阴性的46,XX核型。我们成功地进行了两阶段尿道成形术，采用颊黏膜移植来重建他的阴茎阴囊型尿道下裂。