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[瑞士的临床尸检:一份现状报告]

[Clinical autopsies in Switzerland : A status report].

作者信息

Rodewald A-K, Bode P, Cathomas G, Moch H

机构信息

Institut für Pathologie und Molekularpathologie, UniversitätsSpital Zürich, Rämistrasse 100, 8091, Zürich, Schweiz.

Institut für Pathologie, Kantonsspital Baselland, Liestal, Schweiz.

出版信息

Pathologe. 2017 Sep;38(5):416-421. doi: 10.1007/s00292-017-0323-8.

DOI:10.1007/s00292-017-0323-8
PMID:28752179
Abstract

BACKGROUND

The number of autopsies has been steadily declining worldwide over the past decades. The reasons for this are diverse. Legislation regarding opposition and consent rules does not appear to have had a significant impact on the autopsy rates. Above all, structural causes and the attitude of the medical profession are the reasons for this decline. The main argument for a high autopsy rate is the identification of diagnostic errors; however, diagnostic discrepancies are relatively independent of the rate of autopsies performed. At the University Hospital (UniversitätsSpital) Zurich it could be shown in a study that from 1972-2002 the frequency of relevant diagnostic discrepancies (classes I and II) decreased from 30% to 7%.

OBJECTIVE

The aim of this article is to present the necessity of a stable autopsy rate and to examine the situation of the autopsy in Switzerland.

MATERIAL AND METHODS

For this purpose, the importance of autopsies in the fields of quality assurance of medical diagnostics, cancer statistics, medical research as well as further education of doctors in Switzerland is shown. Efforts are being made by the pathologists to counteract the declining autopsy rates.

RESULTS AND DISCUSSION

Declining autopsy numbers have a significant influence on cancer statistics. The rate of newly discovered tumors in autopsies in Switzerland decreased from 42% in 1980 to 17% in 2010. Pediatric autopsies are an important tool for quality assurance of medical diagnostics in neonatology and pediatrics in Switzerland, but the rate of autopsies carried out is also declining. Postmortem magnetic resonance imaging (MRI) examinations (virtopsy) could increase the acceptance of the parents for an autopsy in the future. Autopsies make an important contribution in research and in documentation of therapy-associated side effects and they are an important component of further education of the upcoming medical generations.

摘要

背景

在过去几十年里,全球尸检数量一直在稳步下降。其原因多种多样。关于反对和同意规则的立法似乎并未对尸检率产生重大影响。最重要的是,结构原因和医学专业人员的态度是导致这种下降的原因。支持高尸检率的主要论据是识别诊断错误;然而,诊断差异相对独立于所进行的尸检率。在苏黎世大学医院的一项研究表明,从1972年至2002年,相关诊断差异(I类和II类)的频率从30%降至7%。

目的

本文旨在阐述稳定尸检率的必要性,并审视瑞士的尸检情况。

材料与方法

为此,展示了尸检在瑞士医学诊断质量保证、癌症统计、医学研究以及医生继续教育等领域的重要性。病理学家正在努力应对尸检率下降的问题。

结果与讨论

尸检数量的下降对癌症统计有重大影响。瑞士尸检中新发现肿瘤的比例从1980年的42%降至2010年的17%。儿科尸检是瑞士新生儿科和儿科医学诊断质量保证的重要工具,但进行的尸检率也在下降。死后磁共振成像(MRI)检查(虚拟尸检)未来可能会提高家长对尸检的接受度。尸检在研究以及记录治疗相关副作用方面做出了重要贡献,并且是未来医学人才继续教育的重要组成部分。

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Can low autopsy rates be increased? Yes, we can! Should postmortem examinations in oncology be performed? Yes, we should! A postmortem analysis of oncological cases.低尸检率能否提高?可以!肿瘤学中的尸检检查是否应该进行?应该!肿瘤病例的死后分析。
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本文引用的文献

1
Value of postmortem studies in deceased neonatal and pediatric intensive care unit patients.新生儿及儿科重症监护病房死亡患者尸检研究的价值
Virchows Arch. 2017 Feb;470(2):217-223. doi: 10.1007/s00428-016-2056-0. Epub 2016 Dec 14.
2
Hypophysitis Secondary to Cytotoxic T-Lymphocyte-Associated Protein 4 Blockade: Insights into Pathogenesis from an Autopsy Series.细胞毒性T淋巴细胞相关蛋白4阻断继发的垂体炎:来自尸检系列的发病机制见解
Am J Pathol. 2016 Dec;186(12):3225-3235. doi: 10.1016/j.ajpath.2016.08.020. Epub 2016 Oct 15.
3
Pathology of congenital Zika syndrome in Brazil: a case series.
英国结核病通报患者的死亡趋势及全因死亡率过高的风险因素:监测数据分析
ERJ Open Res. 2019 Dec 16;5(4). doi: 10.1183/23120541.00125-2019. eCollection 2019 Oct.
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Changes in Clinical and Legal Autopsy Rates in Korea from 2001 to 2015.2001 年至 2015 年韩国临床和法律尸检率的变化。
J Korean Med Sci. 2019 Dec 9;34(47):e301. doi: 10.3346/jkms.2019.34.e301.
5
Implementation of modern tools in autopsy practice-the way towards contemporary postmortal diagnostics.在尸检实践中应用现代工具——走向当代死后诊断的途径。
Virchows Arch. 2019 Feb;474(2):149-158. doi: 10.1007/s00428-018-2482-2. Epub 2018 Nov 13.
巴西先天性寨卡综合征的病理学:病例系列研究。
Lancet. 2016 Aug 27;388(10047):898-904. doi: 10.1016/S0140-6736(16)30883-2. Epub 2016 Jun 29.
4
Changes in autopsy rates among cancer patients and their impact on cancer statistics from a public health point of view: a longitudinal study from 1980 to 2010 with data from Cancer Registry Zurich.从公共卫生角度看癌症患者尸检率的变化及其对癌症统计数据的影响:一项基于苏黎世癌症登记处1980年至2010年数据的纵向研究
Virchows Arch. 2015 Jun;466(6):637-43. doi: 10.1007/s00428-015-1734-7. Epub 2015 Mar 7.
5
Diagnostic errors in the pediatric and neonatal ICU: a systematic review.儿科和新生儿重症监护病房的诊断错误:系统评价。
Pediatr Crit Care Med. 2015 Jan;16(1):29-36. doi: 10.1097/PCC.0000000000000274.
6
Minimally invasive, imaging guided virtual autopsy compared to conventional autopsy in foetal, newborn and infant cases: study protocol for the paediatric virtual autopsy trial.微创、影像引导虚拟尸检与胎儿、新生儿和婴儿常规尸检的比较:儿科虚拟尸检试验研究方案。
BMC Pediatr. 2014 Jan 20;14:15. doi: 10.1186/1471-2431-14-15.
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Virchows Arch. 2012 Jul;461(1):87-92. doi: 10.1007/s00428-012-1262-7. Epub 2012 Jun 21.
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