Wirostko E, Johnson L A, Wirostko B M
Lancet. 1986 Aug 30;2(8505):481-3. doi: 10.1016/s0140-6736(86)90357-0.
Vitreous humour from chronic idiopathic vitritis (CIV) patients containing 0.5-0.7 micron diameter bacteria-like bodies (BLB) in polymorphonuclear leucocytes was inoculated into the eyelids of 100 mice. 200 control mice received either eye-bank vitreous or saline. After 12 months, 53 mice that received CIV vitreous, but none of the controls, had clinical signs of ocular inflammation (p less than 0.05); 15 of the mice that received CIV vitreous and none of the controls had histological evidence of chronic deep ocular inflammation, including vitritis (p less than 0.05); 95 CIV-vitreous-inoculated and 38 control mice were dead (p less than 0.05); and 3/3 of the CIV-vitreous group, compared with 0/3 controls, that were killed for histological assessment had phagolysosomal BLB identical to those in the CIV-vitreous inocula. The findings indicate that the BLB are pathogenic for mice.
将来自慢性特发性葡萄膜炎（CIV）患者、在多形核白细胞中含有直径0.5 - 0.7微米的类菌体（BLB）的玻璃体液接种到100只小鼠的眼睑中。200只对照小鼠接受眼库玻璃体液或生理盐水。12个月后，接受CIV玻璃体液的53只小鼠出现眼部炎症的临床体征，而对照组小鼠均未出现（p < 0.05）；接受CIV玻璃体液的15只小鼠有慢性深部眼部炎症的组织学证据，包括葡萄膜炎，而对照组小鼠均未出现（p < 0.05）；95只接种CIV玻璃体液的小鼠和38只对照小鼠死亡（p < 0.05）；为进行组织学评估而处死的CIV玻璃体液组的3只小鼠中，有3只的吞噬溶酶体BLB与接种的CIV玻璃体液中的BLB相同，而对照组的3只小鼠均未出现这种情况。这些发现表明BLB对小鼠具有致病性。
