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用随机传播对SI传染病进行建模:双曲线发病率。

Modeling a SI epidemic with stochastic transmission: hyperbolic incidence rate.

作者信息

Christen Alejandra, Maulén-Yañez M Angélica, González-Olivares Eduardo, Curé Michel

机构信息

Instituto de Estadística, Pontificia Universidad Católica de Valparaíso, Errázuriz 2734, Valparaiso, Chile.

Pontificia Universidad Católica de Valparaíso, Brasil 2950, Valparaiso, Chile.

出版信息

J Math Biol. 2018 Mar;76(4):1005-1026. doi: 10.1007/s00285-017-1162-1. Epub 2017 Jul 27.

Abstract

In this paper a stochastic susceptible-infectious (SI) epidemic model is analysed, which is based on the model proposed by Roberts and Saha (Appl Math Lett 12: 37-41, 1999), considering a hyperbolic type nonlinear incidence rate. Assuming the proportion of infected population varies with time, our new model is described by an ordinary differential equation, which is analogous to the equation that describes the double Allee effect. The limit of the solution of this equation (deterministic model) is found when time tends to infinity. Then, the asymptotic behaviour of a stochastic fluctuation due to the environmental variation in the coefficient of disease transmission is studied. Thus a stochastic differential equation (SDE) is obtained and the existence of a unique solution is proved. Moreover, the SDE is analysed through the associated Fokker-Planck equation to obtain the invariant measure when the proportion of the infected population reaches steady state. An explicit expression for invariant measure is found and we study some of its properties. The long time behaviour of deterministic and stochastic models are compared by simulations. According to our knowledge this incidence rate has not been previously used for this type of epidemic models.

摘要

本文分析了一种随机易感-感染(SI)流行病模型,该模型基于罗伯茨和萨哈提出的模型(《应用数学快报》12:37 - 41,1999),考虑了一种双曲型非线性发病率。假设感染人群的比例随时间变化,我们的新模型由一个常微分方程描述,该方程类似于描述双Allee效应的方程。当时间趋于无穷时,求出了该方程(确定性模型)解的极限。然后,研究了由于疾病传播系数的环境变化引起的随机波动的渐近行为。由此得到一个随机微分方程(SDE),并证明了其唯一解的存在性。此外,通过相关的福克 - 普朗克方程对该SDE进行分析,以获得感染人群比例达到稳态时的不变测度。找到了不变测度的显式表达式,并研究了其一些性质。通过模拟比较了确定性模型和随机模型的长期行为。据我们所知,这种发病率以前尚未用于此类流行病模型。

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