Watt G, Adapon B, Long G W, Fernando M T, Ranoa C P, Cross J H
Lancet. 1986 Sep 6;2(8506):529-32. doi: 10.1016/s0140-6736(86)90110-8.
The effectiveness of standard single-day praziquantel treatment (60 mg/kg) was prospectively evaluated in nine patients with seizures caused by cerebral Schistosoma japonicum infection. Eight patients were cured when discharged from the study, an average of 6 months after receiving praziquantel. They were seizure-free in the absence of anticonvulsants, their electroencephalograms were normal, and no major abnormalities could be detected on neurological examination. Serial computed tomography scanning revealed rapid dissipation of cerebral oedema and complete or near-complete resolution of mass lesions. No serious adverse effects of praziquantel were encountered. The ninth patient was not cured but improved greatly in the months after treatment. Thus, single-day treatment with praziquantel is safe and effective in cerebral schistosomiasis.
对9例由日本血吸虫感染脑部引起癫痫发作的患者，前瞻性评估了标准单剂量吡喹酮治疗（60mg/kg）的疗效。8例患者在研究结束时（接受吡喹酮治疗后平均6个月）治愈。他们在未服用抗惊厥药物的情况下无癫痫发作，脑电图正常，神经系统检查未发现重大异常。连续计算机断层扫描显示脑水肿迅速消退，肿块病变完全或几乎完全消退。未发现吡喹酮的严重不良反应。第9例患者未治愈，但在治疗后的几个月里有很大改善。因此，吡喹酮单剂量治疗日本血吸虫病性脑部感染安全有效。
