Matsuzaki Hideki, Terao Takeshi, Inoue Takeshi, Takaesu Yoshikazu, Ishii Nobuyoshi, Kohno Kentaro, Takeshima Minoru, Baba Hajime, Honma Hiroshi
Department of Neuropsychiatry, Oita University Faculty of Medicine, Japan; Matsuzaki Clinic, Japan.
Department of Neuropsychiatry, Oita University Faculty of Medicine, Japan.
J Affect Disord. 2017 Dec 1;223:126-129. doi: 10.1016/j.jad.2017.07.039. Epub 2017 Jul 20.
The Japanese archipelago stretches over 4000km from north to south and has four large islands: Hokkaido, Honshu, Shikoku, and Kyushu. Previously, using the Temperament Evaluation of Memphis, Pisa, Paris and San Diego-auto questionnaire version (TEMPS-A), we compared the hyperthymic scores of residents in Sapporo, Obihiro, Takaoka, Koshigaya, and Oita cities (which are located at latitudes of 43°N, 42°N, 36°N, 36°N and 33°N with various combinations of ambient temperament and sunshine in Japan, respectively). We found that latitude predicted significant variance in hyperthymic temperament, and that ambient temperature, but not sunshine, significantly affected hyperthymic temperament scores. However, the analysis failed to consider the effects of naturally occurring low-dose lithium on temperament.
In addition to the TEMPS-A data previously collected, we measured lithium levels of the five cities. The effect of temperature, sunshine, and lithium levels on hyperthymic temperament was analyzed for the five cities.
A stepwise multiple regression analysis revealed that lithium levels as well as latitude, but not temperature or sunshine, predicted significant variance in hyperthymic temperament scores. Hyperthymic temperament scores were significantly and positively associated with lithium levels whereas they were significantly and negatively associated with latitude.
The light, temperature, lithium exposure that residents actually received was not measured. The number of regions studied was limited. The findings might not be generalized to residents across Japan or other countries.
The present findings suggest that lithium in drinking water may positively maintain hyperthymic temperament, and that latitude may negatively maintain it.
日本列岛南北绵延超过4000公里,由四个大岛组成:北海道、本州、四国和九州。此前,我们使用孟菲斯、比萨、巴黎和圣地亚哥气质评估自动问卷版(TEMPS-A),比较了札幌、带广、高冈、越谷和大分市(分别位于北纬43°、42°、36°、36°和33°,日本不同环境气质和日照组合的地区)居民的轻躁狂得分。我们发现纬度可预测轻躁狂气质的显著差异,且环境温度而非日照显著影响轻躁狂气质得分。然而,该分析未考虑天然存在的低剂量锂对气质的影响。
除先前收集的TEMPS-A数据外,我们测量了这五个城市的锂水平。分析了温度、日照和锂水平对这五个城市轻躁狂气质的影响。
逐步多元回归分析显示,锂水平以及纬度而非温度或日照可预测轻躁狂气质得分的显著差异。轻躁狂气质得分与锂水平显著正相关,而与纬度显著负相关。
未测量居民实际接受的光照、温度和锂暴露量。研究地区数量有限。研究结果可能无法推广至日本全国或其他国家的居民。
目前的研究结果表明,饮用水中的锂可能对维持轻躁狂气质有积极作用,而纬度可能对其有消极作用。