Department of Clinical Science, University of Bergen, Bergen, Norway.
Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway.
BJOG. 2018 May;125(6):667-674. doi: 10.1111/1471-0528.14837. Epub 2017 Aug 28.
To assess whether parents who were born small for gestational age (below the 10th birthweight centile, SGA) have increased risk of severe or mild placental abruption. To assess whether a history of SGA in other family members modifies this intergenerational effect.
Prospective population-based observational study.
The Medical Birth Registry of Norway.
From 1967 to 2013, 785 333 mother-offspring pairs, 643 066 father-offspring pairs, 272 941 maternal tetrads (i.e. her offspring, sibling, and niece/nephew), and 265 505 paternal tetrads were identified.
Cohort study based on linked data from the Medical Birth Registry of Norway.
Relative risk (RR) of severe placental abruption (preterm birth, birthweight below the 10th centile, or perinatal death) and mild placental abruption (other cases) in families with SGA.
Mothers who were born SGA had increased risk of severe placental abruption (RR 1.5; 95% confidence interval, 95% CI 1.3-1.8), but not mild abruption. The paternal effects were weaker. The combined effect of SGA in the mother and her sibling on severe abruption was twofold (RR 2.4; 95% CI 1.7-3.3) compared with birthweight centiles ≥10 for both. Similarly, the effect of adding an SGA niece/nephew was twofold (RR 2.3; 95% CI 1.3-3.9), whereas the combined effect of SGA in the mother, her sibling and her niece/nephew was fourfold (RR 3.6; 95% CI 1.9-6.8).
Women who were born SGA have an increased risk of severe placental abruption. The corresponding paternal effect was modest. A history of SGA in other family members increases the generational effect.
Women born small for gestational age have excess risk of placental abruption.
评估出生体重低于第 10 个百分位数（小于胎龄儿，SGA）的父母发生严重或轻度胎盘早剥的风险是否增加。评估其他家庭成员中 SGA 的病史是否会改变这种代际效应。
前瞻性基于人群的观察性研究。
挪威医学出生登记处。
1967 年至 2013 年，共确定了 785333 对母婴、643066 对父子、272941 个母婴四联体（即她的后代、兄弟姐妹和侄女/侄子）和 265505 个父子四联体。
基于挪威医学出生登记处的链接数据进行队列研究。
SGA 家庭中严重胎盘早剥（早产、出生体重低于第 10 百分位数或围产儿死亡）和轻度胎盘早剥（其他病例）的相对风险（RR）。
SGA 出生的母亲发生严重胎盘早剥的风险增加（RR 1.5；95%置信区间，95%CI 1.3-1.8），但不包括轻度胎盘早剥。父亲的影响较弱。SGA 母亲及其兄弟姐妹对严重胎盘早剥的综合影响是出生体重百分位数≥10 的两倍（RR 2.4；95%CI 1.7-3.3）。同样，添加 SGA 侄女/侄子的影响也是两倍（RR 2.3；95%CI 1.3-3.9），而 SGA 母亲、其兄弟姐妹和侄女/侄子的综合影响则增加了四倍（RR 3.6；95%CI 1.9-6.8）。
出生体重小于胎龄的女性发生胎盘早剥的风险增加。相应的父亲效应适度。其他家庭成员中 SGA 的病史会增加代际效应。
出生体重小于胎龄的女性发生胎盘早剥的风险增加。
