Ogawa Kohei, Morisaki Naho, Saito Shigeru, Sato Shoji, Fujiwara Takeo, Sago Haruhiko
Department of Social Medicine, National Center for Child Health and Development, Tokyo, Japan.
Center of Maternal-Fetal, Neonatal and Reproductive Medicine, National Center for Child Health and Development, Tokyo, Japan.
Paediatr Perinat Epidemiol. 2017 May;31(3):198-205. doi: 10.1111/ppe.12351. Epub 2017 Mar 20.
Although adult height is inversely related with the risk of chronic disease, the association between maternal height and ischaemic placental disease remains unclear.
We used the national, multicentre Japan Society of Obstetrics and Gynecology perinatal database to assess the risk of preeclampsia, placental abruption, and small for gestational age (SGA) births (birthweight < 10th percentile), which together constitute the syndrome 'ischaemic placental disease', in relation to self-reported height in 218 412 women with no underlying diseases before pregnancy, who delivered singletons in 2005-11. Height was categorised into quartiles as well as considered in linear terms, and its effect on each outcome was estimated using multivariable log binomial regression adjusted for the maternal characteristics.
The risk of preeclampsia, placental abruption, and SGA birth was inversely related to maternal height. In the adjusted model, mothers in the lowest quartile for height (<155 cm) were at higher risk of preeclampsia (relative risk (RR) 1.35, 95% confidence interval (CI) 1.25, 1.45), placental abruption (RR 1.20, 95% CI 1.07, 1.34), and SGA (RR 1.96, 95% CI 1.90, 2.03) compared with mothers in the highest quartile (>162 cm). When the association between height and outcomes was considered in linear terms, each 5 cm decrement in height was associated with an increased risk of preeclampsia (RR 1.11, 95% CI 1.09, 1.14), placental abruption (RR 1.04, 95% CI 1.01, 1.09), and SGA birth (RR 1.30, 95% CI 1.28, 1.31).
Shorter height was associated with an increased risk of preeclampsia, placental abruption, and SGA birth.
尽管成人身高与慢性病风险呈负相关，但母亲身高与缺血性胎盘疾病之间的关联仍不明确。
我们使用日本妇产科学会全国多中心围产期数据库，评估2005年至2011年期间分娩单胎、孕前无基础疾病的218412名女性中，子痫前期、胎盘早剥和小于胎龄儿（SGA）出生（出生体重<第10百分位数）的风险，这些情况共同构成“缺血性胎盘疾病”综合征，与自我报告的身高相关。身高被分为四分位数，并以线性方式考虑，其对每个结局的影响通过对母亲特征进行调整的多变量对数二项回归进行估计。
子痫前期、胎盘早剥和SGA出生的风险与母亲身高呈负相关。在调整模型中，身高处于最低四分位数（<155cm）的母亲患子痫前期（相对风险（RR）1.35，95%置信区间（CI）1.25，1.45）、胎盘早剥（RR 1.20，95%CI 1.07，1.34）和SGA（RR 1.96，95%CI 1.90，2.03）的风险高于身高处于最高四分位数（>162cm）的母亲。当以线性方式考虑身高与结局之间的关联时，身高每降低5cm，子痫前期（RR 1.11，95%CI 1.09，1.14）、胎盘早剥（RR 1.04，95%CI 1.01，1.09）和SGA出生（RR 1.30，95%CI 1.28，1.31）的风险增加。
身高较矮与子痫前期、胎盘早剥和SGA出生风险增加有关。
