6,6'-二氨基-6,6'-二脱氧海藻糖的合成及其抗氧化能力

Synthesis and antioxidant ability of 6,6'-diamino-6,6'-dideoxytrehalose.

作者信息

Tan Wenqiang, Li Qing, Zhou Tingting, Chen Qiuhong, Wang Gang, Dong Fang, Guo Zhanyong

机构信息

Key Laboratory of Coastal Biology and Bioresource Utilization, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China; University of Chinese Academy of Sciences, Beijing 100049, China.

Key Laboratory of Coastal Biology and Bioresource Utilization, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China.

出版信息

Bioorg Chem. 2017 Oct;74:66-71. doi: 10.1016/j.bioorg.2017.07.005. Epub 2017 Jul 20.

DOI:10.1016/j.bioorg.2017.07.005

PMID:28755563

Abstract

In order to study the influence of amino group on antioxidant activity of oligosaccharides, an amino disaccharide, 6,6'-diamino-6,6'-dideoxytrehalose (DAMDT) was successfully prepared in this paper, and its antioxidant activities against DPPH, superoxide, hydrogen peroxide, and hydroxyl radicals, and reducing power were evaluated, respectively. The results indicated that DAMDT had better antioxidant activity than trehalose at any tested concentration. The influence of amino group on antioxidant activity of disaccharides is positive based on the results in this paper, and amination should be an effective method to improve the bioactivity of saccharides.

摘要

为了研究氨基对寡糖抗氧化活性的影响，本文成功制备了一种氨基二糖，即6,6'-二氨基-6,6'-二脱氧海藻糖（DAMDT），并分别评价了其对DPPH、超氧阴离子、过氧化氢和羟基自由基的抗氧化活性以及还原能力。结果表明，在任何测试浓度下，DAMDT的抗氧化活性均优于海藻糖。基于本文结果，氨基对二糖抗氧化活性的影响是积极的，胺化应该是提高糖类生物活性的有效方法。