Swathi Konda, Sarangapani Manda
Medicinal Chemistry Laboratory, U.C.P.Sc., Kakatiya University, Warangal, 506009, Telangana, India,
Adv Exp Med Biol. 2015;822:129-37. doi: 10.1007/978-3-319-08927-0_14.
In the present work, some new 5-Hydroxyindole 3-thiosemicarbazone 2-ones and 5-[2(3)-dialkylaminoalkoxy] Indole 3-hydrazone 2-ones were prepared from 5-hydroxy isatin. The structures of the products were characterized by IR, NMR, and MASS Spectral studies. All the compounds were examined for antioxidant activity by using 1,1-diphenyl-2-picryl-hydrazyl and hydrogen peroxide (H2O2), and the total antioxidant capacity by a phosphomolybdenum assay. In general, the derivatives were found to exhibit antioxidant activity. Further, the compounds with dialkyl amino alkoxy at the C5 position demonstrated significant antioxidant activity.
在本研究中，由5-羟基异吲哚酮制备了一些新型的5-羟基吲哚-3-硫代半卡巴腙-2-酮和5-[2(3)-二烷基氨基烷氧基]吲哚-3-腙-2-酮。通过红外光谱、核磁共振光谱和质谱研究对产物结构进行了表征。使用1,1-二苯基-2-苦基肼和过氧化氢（H₂O₂）对所有化合物进行抗氧化活性检测，并通过磷钼酸法测定总抗氧化能力。总体而言，发现这些衍生物具有抗氧化活性。此外，在C5位带有二烷基氨基烷氧基的化合物表现出显著的抗氧化活性。
