Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University College of Public Health, Taipei, Taiwan.
Institute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan; Department of Pediatrics, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
Sci Total Environ. 2017 Dec 31;609:396-409. doi: 10.1016/j.scitotenv.2017.07.081. Epub 2017 Jul 26.
Numerous studies have explored the associations between environmental pollutants and pediatric health. Recent studies have investigated the issue in Asia, but no systematic review has been published to date. This study aims to elucidate the issue by summarizing relevant epidemiologic evidence for cohorts in Asia, using information from the Birth Cohort Consortium of Asia (BiCCA). Environmental pollutants include mercury, environmental tobacco smoke (ETS), polychlorinated biphenyls (PCB), perfluoroalkyl substances (PFAS) and phthalates. This study sought to classify the effects of such compounds on fetal growth and pregnancy outcomes, neurodevelopment and behavioral problems, allergic disease and immune function and the endocrine system and puberty. These evidences showed ETS has been associated with infant birth weight, children's neurodevelopment and allergy disease; mercury and PCB have been shown to affect children's neurodevelopment; phthalate has effects on endocrine function; PFAS alters children's neurodevelopment, the endocrine system, and the allergic response. However, more consistent and coordinated research is necessary to understand the whole picture of single environmental and/or co-exposure and children's health. Therefore, harmonization and international collaboration are also needed in Asia.
许多研究探讨了环境污染物与儿科健康之间的关联。最近的研究已经在亚洲展开，但迄今为止尚未发表系统综述。本研究旨在通过汇总亚洲队列的相关流行病学证据（来自亚洲出生队列联盟）来阐明这一问题。环境污染物包括汞、环境烟草烟雾 (ETS)、多氯联苯 (PCB)、全氟烷基物质 (PFAS) 和邻苯二甲酸酯。本研究旨在对这些化合物对胎儿生长和妊娠结局、神经发育和行为问题、过敏疾病和免疫功能以及内分泌系统和青春期的影响进行分类。这些证据表明，ETS 与婴儿出生体重、儿童神经发育和过敏疾病有关；汞和 PCB 已被证明会影响儿童的神经发育；邻苯二甲酸酯对内分泌功能有影响；PFAS 会改变儿童的神经发育、内分泌系统和过敏反应。然而，需要进行更一致和协调的研究，以了解单一环境和/或共同暴露对儿童健康的全面影响。因此，亚洲也需要协调和国际合作。
