Fuentes Fernandez Ignacio, Hernandez-Clares Rocio, Carreón Guarnizo Ester, Meca Lallana Jose E
Critical Care Department, Virgen de la Arrixaca Hospital, Murcia, Spain.
Multiple Sclerosis Unit, Neurology Department, Virgen de la Arrixaca Hospital, Murcia, Spain.
Mult Scler Relat Disord. 2017 Aug;16:22-23. doi: 10.1016/j.msard.2017.06.001. Epub 2017 Jun 6.
61-year-old woman with Neuromyelitis optica (NMO) diagnosis treated with rituximab was referred to our hospital with severe hypovolemic shock and anasarca. The laboratory findings showed marked hemoconcentration and a decrease in total serum protein. She developed a multiple organ failure and died three hours later. We diagnosed the patient as having capillary leak syndrome (CLS). CLS is a very rare condition caused by unexplained episodic capillary hyperpermeability, which can be idiopathic or secondary to some conditions like infection, malignant disease and some drugs like monoclonal antibodies. We reported the first CLS case in NMO patient treated with rituximab.
一名61岁诊断为视神经脊髓炎（NMO）的女性患者，接受利妥昔单抗治疗，因严重低血容量性休克和全身水肿被转诊至我院。实验室检查结果显示明显的血液浓缩和血清总蛋白降低。她出现了多器官功能衰竭，三小时后死亡。我们诊断该患者患有毛细血管渗漏综合征（CLS）。CLS是一种非常罕见的疾病，由不明原因的发作性毛细血管高通透性引起，可为特发性或继发于某些情况，如感染、恶性疾病以及某些药物（如单克隆抗体）。我们报告了首例接受利妥昔单抗治疗的NMO患者发生CLS的病例。
