基于组织学的声诺维增强超声检查对肝转移瘤诊断的评估
Histology-Based Assessment of Sonazoid-Enhanced Ultrasonography for the Diagnosis of Liver Metastasis.
作者信息
Kobayashi Kazufumi, Maruyama Hitoshi, Kiyono Soichiro, Yokosuka Osamu, Ohtsuka Masayuki, Miyazaki Masaru, Matsushima Jun, Kishimoto Takashi, Nakatani Yukio
机构信息
Department of Gastroenterology and Nephrology, Chiba University Graduate School of Medicine, Chuo-ku, Chiba, Japan.
Department of Gastroenterology and Nephrology, Chiba University Graduate School of Medicine, Chuo-ku, Chiba, Japan.
出版信息
Ultrasound Med Biol. 2017 Oct;43(10):2151-2158. doi: 10.1016/j.ultrasmedbio.2017.06.014. Epub 2017 Jul 26.
This retrospective study aimed to assess the diagnostic performance of contrast-enhanced ultrasound with Sonazoid (S-CEUS) for liver metastasis. We enrolled in this study 98 patients with 148 histologically proven liver lesions, with 121 metastases and 27 non-metastases. The S-CEUS technique showed sensitivity in 95.0% (115 of 121), specificity in 44.4% (12 of 27) and accuracy in 85.8% (127 of 148) for the diagnosis of metastasis. Higher body mass index had a negative influence on the positive predictive value and accuracy, and a greater depth of the lesion had a negative influence on the accuracy. The management was changed in 8 patients (8.2%) because of S-CEUS findings. In conclusion, the addition of S-CEUS may offer a great benefit by improvement of the quality of diagnosis and management for patients with cancer who have a tentative diagnosis of liver metastasis by contrast-enhanced computed tomography.
这项回顾性研究旨在评估使用声诺维（S-CEUS）的超声造影对肝转移瘤的诊断性能。我们纳入了本研究中的98例患者，他们有148个经组织学证实的肝脏病变，其中121个为转移瘤，27个为非转移瘤。S-CEUS技术对转移瘤诊断的敏感性为95.0%（121例中的115例），特异性为44.4%（27例中的12例），准确性为85.8%（148例中的127例）。较高的体重指数对阳性预测值和准确性有负面影响，病变深度较大对准确性有负面影响。由于S-CEUS检查结果，8例患者（8.2%）的治疗方案发生了改变。总之，对于经对比增强计算机断层扫描初步诊断为肝转移瘤的癌症患者，增加S-CEUS检查可能会通过提高诊断质量和治疗效果带来很大益处。
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