Kobayashi Kazufumi, Maruyama Hitoshi, Kiyono Soichiro, Yokosuka Osamu, Ohtsuka Masayuki, Miyazaki Masaru, Matsushima Jun, Kishimoto Takashi, Nakatani Yukio
Department of Gastroenterology and Nephrology, Chiba University Graduate School of Medicine, Chuo-ku, Chiba, Japan.
Department of Gastroenterology and Nephrology, Chiba University Graduate School of Medicine, Chuo-ku, Chiba, Japan.
Ultrasound Med Biol. 2017 Oct;43(10):2151-2158. doi: 10.1016/j.ultrasmedbio.2017.06.014. Epub 2017 Jul 26.
This retrospective study aimed to assess the diagnostic performance of contrast-enhanced ultrasound with Sonazoid (S-CEUS) for liver metastasis. We enrolled in this study 98 patients with 148 histologically proven liver lesions, with 121 metastases and 27 non-metastases. The S-CEUS technique showed sensitivity in 95.0% (115 of 121), specificity in 44.4% (12 of 27) and accuracy in 85.8% (127 of 148) for the diagnosis of metastasis. Higher body mass index had a negative influence on the positive predictive value and accuracy, and a greater depth of the lesion had a negative influence on the accuracy. The management was changed in 8 patients (8.2%) because of S-CEUS findings. In conclusion, the addition of S-CEUS may offer a great benefit by improvement of the quality of diagnosis and management for patients with cancer who have a tentative diagnosis of liver metastasis by contrast-enhanced computed tomography.
这项回顾性研究旨在评估使用声诺维（S-CEUS）的超声造影对肝转移瘤的诊断性能。我们纳入了本研究中的98例患者，他们有148个经组织学证实的肝脏病变，其中121个为转移瘤，27个为非转移瘤。S-CEUS技术对转移瘤诊断的敏感性为95.0%（121例中的115例），特异性为44.4%（27例中的12例），准确性为85.8%（148例中的127例）。较高的体重指数对阳性预测值和准确性有负面影响，病变深度较大对准确性有负面影响。由于S-CEUS检查结果，8例患者（8.2%）的治疗方案发生了改变。总之，对于经对比增强计算机断层扫描初步诊断为肝转移瘤的癌症患者，增加S-CEUS检查可能会通过提高诊断质量和治疗效果带来很大益处。
