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与金刚烷胺相关的精神分裂症恶化

Exacerbation of schizophrenia associated with amantadine.

作者信息

Nestelbaum Z, Siris S G, Rifkin A, Klar H, Reardon G T

出版信息

Am J Psychiatry. 1986 Sep;143(9):1170-1. doi: 10.1176/ajp.143.9.1170.

DOI:10.1176/ajp.143.9.1170
PMID:2875665
Abstract

Administration of amantadine was associated with psychotic decompensations in two schizophrenic patients being maintained on concomitant neuroleptic medication. Despite a postulated dopaminergic mechanism, there seems to have been only one previous report of amantadine's precipitating psychosis in a schizophrenic patient.

摘要

在两名正在接受抗精神病药物联合治疗的精神分裂症患者中，金刚烷胺的使用与精神错乱有关。尽管推测其作用机制与多巴胺能有关，但此前似乎仅有一份关于金刚烷胺诱发精神分裂症患者精神病发作的报告。

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Exacerbation of schizophrenia associated with amantadine.与金刚烷胺相关的精神分裂症恶化
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Effect of amantadine on sexual dysfunction in neuroleptic-treated male schizophrenic patients.金刚烷胺对接受抗精神病药物治疗的男性精神分裂症患者性功能障碍的影响。
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All antipsychotics are equal, but some are more equal than others.所有抗精神病药物都是一样的，但有些比其他的更具优势。
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Changes in verbal learning of patients with schizophrenia: Results from a randomized, double-blind, placebo-controlled trial of amantadine adjunctive to antipsychotics.精神分裂症患者言语学习的变化：抗精神病药物联用金刚烷胺的随机、双盲、安慰剂对照试验结果
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No difference in the effect of biperiden and amantadine on negative symptoms in medicated chronic schizophrenic patients.安克痉与金刚烷胺对药物治疗的慢性精神分裂症患者阴性症状的疗效无差异。
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引用本文的文献

1
Amantadine and the glutamate hypothesis of schizophrenia. Experiences in the treatment of neuroleptic malignant syndrome.金刚烷胺与精神分裂症的谷氨酸假说。抗精神病药恶性综合征的治疗经验。
J Neural Transm Gen Sect. 1993;92(1):57-65. doi: 10.1007/BF01245162.
2
Amantadine and rimantadine prophylaxis of influenza A in nursing homes. A tolerability perspective.养老院中金刚烷胺和金刚乙胺对甲型流感的预防：耐受性视角
Drugs Aging. 1994 Jul;5(1):8-19. doi: 10.2165/00002512-199405010-00002.
3
Depression in schizophrenia: current guidelines to treatment.
精神分裂症中的抑郁：当前治疗指南
Psychiatr Q. 1989 Winter;60(4):337-57. doi: 10.1007/BF01064357.