Can Nhu Thuy, Grenert James P, Vohra Poonam
Department of Pathology, University of California, San Francisco, CA, USA.
Department of Pathology, University of California, San Francisco, CA, USA.
Pathol Res Pract. 2017 Oct;213(10):1306-1309. doi: 10.1016/j.prp.2017.07.008. Epub 2017 Jul 13.
Epstein-Barr Virus-associated smooth muscle tumor (EBV-SMT) is a rare mesenchymal tumor typically seen in immunocompromised patients. Here, we report a case of EBV-SMT and associated granulomatous inflammation in the liver of a 32-year-old man with history of human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS). To our knowledge, an association of these two lesions has not been previously reported. We review the literature and discuss pathogenesis, differential diagnosis and immunohistochemical (IHC) stains helpful for the diagnosis of this rare entity. Finally, we consider possible explanations for the concomitant presence of these lesions.
爱泼斯坦-巴尔病毒相关平滑肌瘤（EBV-SMT）是一种罕见的间叶组织肿瘤，通常见于免疫功能低下的患者。在此，我们报告一例32岁男性肝脏中的EBV-SMT及相关肉芽肿性炎症，该患者有人免疫缺陷病毒/获得性免疫缺陷综合征（HIV/AIDS）病史。据我们所知，此前尚未报道过这两种病变的关联。我们回顾文献并讨论其发病机制、鉴别诊断以及有助于诊断这种罕见实体的免疫组织化学（IHC）染色。最后，我们考虑这些病变同时存在的可能原因。
