高血压患者循环中Th1、Th2和Th17水平
Circulating Th1, Th2, and Th17 Levels in Hypertensive Patients.
作者信息
Ji Qingwei, Cheng Guojie, Ma Ning, Huang Ying, Lin Yingzhong, Zhou Qi, Que Bin, Dong Jianzeng, Zhou Yujie, Nie Shaoping
机构信息
Emergency & Critical Care Center, Beijing Anzhen Hospital, Capital Medical University, and Beijing Institute of Heart, Lung, and Blood Vessel Diseases, Beijing 100029, China.
Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, and Beijing Institute of Heart, Lung, and Blood Vessel Diseases, The Key Laboratory of Remodeling-Related Cardiovascular Disease, Ministry of Education, Beijing 100029, China.
出版信息
Dis Markers. 2017;2017:7146290. doi: 10.1155/2017/7146290. Epub 2017 Jul 5.
BACKGROUND
Evidence from experimental studies showed that Th1, Th2, and Th17 play a pivotal role in hypertension and target organ damage. However, whether changes in the circulating Th1, Th2, and Th17 levels are associated with nondipper hypertension and carotid atherosclerotic plaque in hypertension has yet to be investigated.
METHODS
Th1, Th2, and Th17 levels were detected using a flow cytometric analysis, and their related cytokines were measured by enzyme-linked immunosorbent assay in 45 hypertensive patients and 15 normotensive subjects.
RESULTS
The frequencies of Th1 and Th17 in hypertensive patients, especially in nondipper patients and patients with carotid atherosclerotic plaque, were markedly higher than those in the control group; this was accompanied by higher IFN- and IL-17 levels. In contrast, the Th2 frequencies and IL-4 levels in hypertensive patients, especially in nondipper patients and patients with carotid atherosclerotic plaque, were significantly lower than those in the control group.
CONCLUSIONS
The changes in Th1, Th2, and Th17 activity are associated with the onset of the nondipper type and carotid atherosclerotic plaque in hypertensive patients.
背景
实验研究证据表明，Th1、Th2和Th17在高血压及靶器官损害中起关键作用。然而，循环中Th1、Th2和Th17水平的变化是否与高血压患者的非勺型高血压及颈动脉粥样硬化斑块相关，尚未得到研究。
方法
采用流式细胞术分析检测45例高血压患者和15例血压正常受试者的Th1、Th2和Th17水平，并用酶联免疫吸附测定法检测其相关细胞因子。
结果
高血压患者，尤其是非勺型高血压患者和伴有颈动脉粥样硬化斑块的患者，其Th1和Th17频率显著高于对照组，同时伴有较高的IFN-γ和IL-17水平。相反，高血压患者，尤其是非勺型高血压患者和伴有颈动脉粥样硬化斑块的患者，其Th2频率和IL-4水平显著低于对照组。
结论
Th1、Th2和Th17活性的变化与高血压患者非勺型高血压的发生及颈动脉粥样硬化斑块有关。
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