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病例报告:成年女性肺癌患者复发性舌黏液表皮样癌

Case Report: Recurrent Mucoepidermoid Carcinoma of the Tongue in Adult Female Patient With Lung Cancer.

作者信息

Rubin Arielle, Davis John, Jreije Karim, Wu Henry, Oppenheimer Randy

机构信息

Otolaryngology Section, Department of Surgery, Maricopa Medical Center, Maricopa Integrated Health System (MIHS), Phoenix, AZ, USA.

出版信息

Clin Med Insights Ear Nose Throat. 2017 Jul 13;10:1179550617720462. doi: 10.1177/1179550617720462. eCollection 2017.

Abstract

There is a steady rise in incidence of malignant salivary gland tumors in the United States, with mucoepidermoid carcinoma (MEC) the most frequent. Although 40% of MECs are found in the parotid gland, these lesions possess the capacity to develop anywhere along the aerodigestive tract. Here, we present a case of recurrent tongue MEC in a young adult female patient with history of lung malignancy and multiple brain metastases. Without a universally accepted management protocol for recurrent MECs, the current clinical practice uses tumor grade, location, and clinical progression to determine both prognosis and goals of care. The patient had transoral laser excision of the first MEC lesion in 2013. Her tongue MEC recurred 3 years later with 2 distinct lesions. One was discovered on physical examination and computed tomography and the other diagnosed intraoperatively 1 month later. These lesions were located on a previously unaffected portion of dorsal tongue base. These lesions were completely excised in the operating room. The patient currently remains on chemotherapy. This underscores the importance for developing a guideline that delineates the most efficacious surveillance and treatment plans for recurrent MECs.

摘要

在美国,恶性唾液腺肿瘤的发病率呈稳步上升趋势,其中黏液表皮样癌(MEC)最为常见。尽管40%的MEC发生于腮腺,但这些病变有能力在整个气道消化道的任何部位发生。在此,我们报告一例年轻成年女性复发性舌部MEC病例,该患者有肺癌病史且发生多处脑转移。由于目前尚无针对复发性MEC的普遍接受的管理方案,当前临床实践根据肿瘤分级、位置和临床进展来确定预后和治疗目标。该患者于2013年经口激光切除首个MEC病变。3年后,她的舌部MEC复发,出现2个不同的病变。一个通过体格检查和计算机断层扫描发现,另一个在1个月后手术中确诊。这些病变位于舌背基部先前未受影响的部位。这些病变在手术室中被完全切除。该患者目前仍在接受化疗。这凸显了制定一项指南的重要性,该指南应明确复发性MEC最有效的监测和治疗方案。

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