甲状腺素对离体牛蛙心脏的负性变时作用。
Negative chronotropic effects of thyroxine on the isolated bullfrog heart.
作者信息
Tamura T, Horiuchi E, Hayashi H, Dohi Y
出版信息
Comp Biochem Physiol A Comp Physiol. 1986;84(4):759-61. doi: 10.1016/0300-9629(86)90401-9.
PMID:2875845
Abstract
An acute application of L-thyroxine (T4) to everted sinus-atrium preparations of bullfrog showed negative chronotropic effects consisting of two processes: an initial peak at 2-5 min and a delayed plateau at 40-60 min. The initial effect was blocked by Cd2+ and tetraethyl-ammonium (TEA). The delayed effect was suppressed by Cd2+ and NaCN.
摘要
将L-甲状腺素（T4）急性应用于牛蛙翻转的窦房结标本时，显示出负性变时作用，该作用由两个过程组成：2 - 5分钟时出现初始峰值，40 - 60分钟时出现延迟平台期。初始效应可被Cd2 +和四乙铵（TEA）阻断。延迟效应可被Cd2 +和NaCN抑制。
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