在离体犬心房中，鸟苷对心率和心肌收缩力有正向反应。

Positive chronotropic and inotropic responses to guanosine in the isolated dog atrium.

作者信息

Chiba S, Kobayashi M, Furukawa Y

出版信息

Eur J Pharmacol. 1978 Jun 1;49(3):319-21. doi: 10.1016/0014-2999(78)90110-3.

Abstract

The effects of guanosine on chronotropism and inotropism in isolated dog atria were studied in spontaneously beating preparations which were suspended in a bath perfused with arterial blood from a carotid artery of a heparinized support dog. Guanosine administered into the cannulated sinus node artery in a dose range of 30 microgram to 3 mg produced a dose-related positive inotropic and chronotropic effect. The positive responses to guanosine were not inhibited by treatment with propranolol or a non-depressant beta-blocker, carteolol, in doses which blocked responses to norepinephrine. From these results, it is concluded that guanosine has a direct effect on atrial rate and contractility.

摘要

在自发搏动的离体犬心房标本中研究了鸟苷对变时性和变力性的影响。该标本悬浮于充满来自肝素化供血犬颈动脉动脉血的浴槽中。经插管的窦房结动脉给予30微克至3毫克剂量范围的鸟苷，可产生剂量相关的正性变力性和变时性作用。在能阻断对去甲肾上腺素反应的剂量下，用普萘洛尔或非抑制性β受体阻滞剂卡替洛尔处理，对鸟苷的阳性反应并未受到抑制。从这些结果得出结论，鸟苷对心房率和收缩力有直接作用。