Kim Hee-Sun, Hwang Han-Sung, Kwon Han-Sung, Lim Ji-Young, Sohn In-Sook
a Division of Maternal and Fetal Medicine, Department of Obstetrics and Gynecology , Ilsan Paik Hospital, College of Medicine, Inje University , Goyang , Kyeogi-do , Korea.
b Division of Maternal and Fetal Medicine, Department of Obstetrics and Gynecology , Research Institute of Medical Science, Konkuk University School of Medicine , Seoul , Korea.
J Matern Fetal Neonatal Med. 2018 Oct;31(20):2748-2755. doi: 10.1080/14767058.2017.1355899. Epub 2017 Jul 31.
This study aimed to compare maternal 25-hydroxyvitamin D (25(OH)D) serum levels during pregnancy in women with and without gestational diabetes mellitus (GDM) with neonatal 25(OH)D serum levels and to evaluate the relationship between maternal and fetal 25(OH)D in the two groups.
Between May 2014 and March 2015, 87 pregnant women were enrolled. The study population was divided into two groups, those with and without GDM (n = 32 and 55). All participants were surveyed about lifestyle and behavior. Maternal and umbilical venous blood samples were obtained. Serum from maternal blood was analyzed for 25(OH)D and 25(OH)D, and umbilical venous blood for 25(OH)D, 25(OH)D, and 3-epi-25(OH)D.
The maternal serum level of 25(OH)D and the 25(OH)D and 3-epi-25(OH)D levels in umbilical venous blood were significantly lower in women with GDM (p < .01 for all comparisons). The maternal blood levels of 25(OH)D, 25(OH)D, and total 25(OH)D were positively correlated with their levels in umbilical venous blood in the total, normal, and GDM groups.
The serum 25(OH)D and 3-epi-25(OH)D levels of babies from mothers with GDM are lower than in pregnant women without GDM.
本研究旨在比较患有和未患有妊娠期糖尿病（GDM）的孕妇孕期血清25-羟基维生素D（25(OH)D）水平与新生儿血清25(OH)D水平，并评估两组中母胎25(OH)D之间的关系。
2014年5月至2015年3月期间，招募了87名孕妇。研究人群分为两组，即患有和未患有GDM的孕妇（n = 32和55）。对所有参与者进行了生活方式和行为调查。采集了孕妇和脐静脉血样本。分析孕妇血液中的血清25(OH)D和25(OH)D，以及脐静脉血中的25(OH)D、25(OH)D和3-表-25(OH)D。
患有GDM的女性孕妇血清25(OH)D水平以及脐静脉血中25(OH)D和3-表-25(OH)D水平显著较低（所有比较p <.01）。在总体、正常和GDM组中，孕妇血液中25(OH)D、25(OH)D和总25(OH)D水平与脐静脉血中的水平呈正相关。
患有GDM的母亲所生婴儿的血清25(OH)D和3-表-25(OH)D水平低于未患GDM的孕妇。
