Whitaker Daniel, Batuecas María, Ricci Paolo, Larrosa Igor
School of Chemistry, University of Manchester, Oxford Road, Manchester, M13 9PL, UK.
Chemistry. 2017 Sep 18;23(52):12763-12766. doi: 10.1002/chem.201703527. Epub 2017 Sep 7.
A strategy for assembling biaryls linked through a medium-sized ring is herein presented. π-Complexation of fluoroarenes to chromium tricarbonyl activates the molecule towards both C-H activation and nucleophilic aromatic substitution without covalently altering the molecular connectivity of the arene. The construction of bridged biaryl molecules with 6-10-membered core rings is achieved through a one-pot C-H arylation/nucleophilic aromatic substitution sequence. The methodology is applicable to the synthesis of heterocyclic as well as fully carbocyclic rings.
本文提出了一种通过中等大小的环连接组装联芳基的策略。氟代芳烃与三羰基铬的π-络合作用使分子在不共价改变芳烃分子连接性的情况下，对C-H活化和亲核芳香取代均具有活性。通过一锅法C-H芳基化/亲核芳香取代序列可实现具有6至10元核心环的桥连联芳基分子的构建。该方法适用于杂环以及全碳环的合成。
