Materials Chemistry Research Centre, Department of Chemistry, University College London , 20 Gordon Street, London WC1H 0AJ, United Kingdom.
Department of Microbial Diseases, UCL Eastman Dental Institute, University College London , 256 Gray's Inn Road, London WC1X 8LD, United Kingdom.
ACS Appl Mater Interfaces. 2017 Aug 30;9(34):29002-29009. doi: 10.1021/acsami.7b05977. Epub 2017 Aug 15.
Bacterial adhesion and proliferation on surfaces are a challenge in medical and industrial fields. Here, a simple one-step technique is reported to fabricate self-cleaning and bactericidal surfaces. White, blue, and violet paints were produced using titanium dioxide nanoparticles, 1H,1H,2H,2H-perfluorooctyltriethoxysilane, crystal violet, toluidine Blue O, and ethanol solution. All of the painted surfaces showed superhydrophobicity in air, and even after hexadecane oil contamination, they retained water repellency and self-cleaning properties. In an assay of bacterial adhesion, significant reductions (>99.8%) in the number of adherent bacteria were observed for all the painted surfaces. In bactericidal tests, the painted surfaces not only demonstrated bactericidal activity against Staphylococcus aureus and Escherichia coli in the dark but also induced very potent photosensitization (>4.4 log reduction in the number of viable bacteria on the violet painted surface) under white light illumination. The technique that we developed here is general and can be used on a wide range of substrates such as paper, glass, polymers, and others.
细菌在表面的黏附和增殖是医学和工业领域面临的挑战。本研究报道了一种简单的一步法技术，可用于制备自清洁和杀菌表面。通过使用纳米二氧化钛、1H，1H，2H，2H-全氟辛基三乙氧基硅烷、结晶紫、甲苯胺蓝 O 和乙醇溶液制备了白色、蓝色和紫色油漆。所有涂漆表面在空气中均表现出超疏水性，即使在十六烷油污染后，仍保持拒水和自清洁性能。在细菌黏附实验中，所有涂漆表面均观察到黏附细菌数量显著减少（>99.8%）。在杀菌测试中，涂漆表面不仅在黑暗中对金黄色葡萄球菌和大肠杆菌表现出杀菌活性，而且在白光照射下还能诱导很强的光敏化作用（紫色涂漆表面上存活细菌数量减少>4.4 log）。我们开发的这种技术具有通用性，可以应用于广泛的基底，如纸张、玻璃、聚合物等。
