Blank M A, Gu J, Allen J M, Huang W M, Yiangou Y, Ch'ng J, Lewis G, Elder M G, Polak J M, Bloom S R
Int J Fertil. 1986 Jul-Aug;31(3):218-22.
The regional distributions of neuropeptide Y (NPY), peptide histidine-methionine (PHM), and vasoactive intestinal polypeptide (VIP) immunoreactivities in the human female genital tract have been estimated by specific radioimmunoassays, and their molecular forms determined by chromatography. The localisation and distribution of these three peptides was carried out by immunocytochemistry. The vagina and cervix contain high concentrations of NPY- and VIP-immunoreactive nerves, mainly localised around the vascular and nonvascular smooth muscle. VIP-containing nerves were, in addition, seen beneath the cervical and, in particular, the vaginal epithelium. A comparatively high level of immunoreactive NPY is found in the fallopian tube, mainly around the circular muscle coat. There is evidence that VIP is a neurotransmitter in the female genital tract, and these results suggest a similar role for NPY and PHM.
通过特异性放射免疫测定法估算了神经肽Y（NPY）、肽组氨酸-甲硫氨酸（PHM）和血管活性肠肽（VIP）免疫反应性在女性生殖道中的区域分布，并通过色谱法确定了它们的分子形式。通过免疫细胞化学对这三种肽进行了定位和分布研究。阴道和子宫颈含有高浓度的NPY和VIP免疫反应性神经，主要分布在血管和非血管平滑肌周围。此外，在子宫颈下方，特别是阴道上皮下方可见含VIP的神经。输卵管中发现较高水平的免疫反应性NPY，主要围绕环形肌层。有证据表明VIP是女性生殖道中的一种神经递质，这些结果提示NPY和PHM可能具有类似作用。
