Perez-Ternero Cristina, Werner Christian M, Nickel Alexander G, Herrera Maria Dolores, Motilva Maria-José, Böhm Michael, Alvarez de Sotomayor Maria, Laufs Ulrich
Klinik für Innere Medizin III-Kardiologie, Angiologie und Internistische Intensivmedizin, Universitätsklinikum des Saarlandes, Homburg/Saar, Germany; Department of Pharmacology, School of Pharmacy, University of Seville, Seville, Spain.
Klinik für Innere Medizin III-Kardiologie, Angiologie und Internistische Intensivmedizin, Universitätsklinikum des Saarlandes, Homburg/Saar, Germany.
J Nutr Biochem. 2017 Oct;48:51-61. doi: 10.1016/j.jnutbio.2017.06.011. Epub 2017 Jun 24.
The aim of the study was to characterize the vascular effects of rice bran enzymatic extract (RBEE). ApoE-/- mice were fed a high-fat/cholesterol diet (HFD) or HFD supplemented with 5% RBEE for 21 weeks. RBEE prevented development of atherosclerotic plaques and oxidative stress in mouse aorta as well as the down-regulation of markers of mitochondrial biogenesis. Analysis of the bioactive components identified ferulic acid (FA) as responsible component. In healthy human volunteers, FA intake reduced NADPH oxidase activity, superoxide release, apoptosis and necrosis in peripheral blood mononuclear cells. Differentiation and proliferation of endothelial progenitor cells were improved. In summary, the study identifies FA as a major active component of rice bran, which improves expression of mitochondrial biogenesis and dynamics markers and reduces oxidative stress in a mouse model of vascular damage as well as in endothelial cells and human mononuclear cells.
本研究的目的是表征米糠酶提取物（RBEE）的血管效应。将载脂蛋白E基因敲除（ApoE-/-）小鼠喂食高脂/胆固醇饮食（HFD）或添加5% RBEE的HFD，持续21周。RBEE可预防小鼠主动脉粥样硬化斑块的形成和氧化应激，以及线粒体生物发生标志物的下调。对生物活性成分的分析确定阿魏酸（FA）为 responsible component。在健康人类志愿者中，摄入FA可降低外周血单核细胞中的NADPH氧化酶活性、超氧化物释放、细胞凋亡和坏死。内皮祖细胞的分化和增殖得到改善。总之，该研究确定FA是米糠的主要活性成分，其可改善线粒体生物发生和动力学标志物的表达，并减少血管损伤小鼠模型以及内皮细胞和人类单核细胞中的氧化应激。
