Zhao Xin, Liao Yan-Nian, Huang Qian
Jinling Hospital, Medical School of Nanjing University, Research Institute of General Surgery, East Zhongshan Road, Xuanwu District, Nanjing, China.
J Int Med Res. 2018 Jan;46(1):11-21. doi: 10.1177/0300060517713856. Epub 2017 Jul 31.
Objective To evaluate the impact of inhibition of the receptor for advanced glycation end products (RAGE) on the outcome of bacterial sepsis in animal models. Methods Relevant publications were identified by systematic searches of PubMed, ISI Web of Science and Elsevier-Scopus databases. Results A total of Eleven studies with moderate quality were selected for analysis. A meta-analysis of survival rates revealed a significant advantage of RAGE inhibition in comparison with controls (HR 0.67, 95% CI 0.52-0.86). This effect was most pronounced in polymicrobial infection (HR 0.28, 95% CI 0.14-0.55), followed by Gram positive (G) bacterial infection (HR 0.70, 95% CI 0.50-0.97) and Gram negative (G) bacterial infection (HR 0.89, 95% CI 0.58-1.38). For G bacterial infection, RAGE inhibition decreased bacterial outgrowth and dissemination, inflammatory cell influx, plasma cytokine levels, and pulmonary injury. Conclusions RAGE inhibition appears to have a beneficial impact on the outcome of sepsis in animal models, although there are discrepancies between different types of infection.
目的 评估抑制晚期糖基化终末产物受体（RAGE）对动物模型中细菌性败血症结局的影响。方法 通过系统检索PubMed、ISI Web of Science和Elsevier-Scopus数据库确定相关出版物。结果 共选择11项质量中等的研究进行分析。生存率的荟萃分析显示，与对照组相比，RAGE抑制具有显著优势（风险比0.67，95%置信区间0.52 - 0.86）。这种效应在多微生物感染中最为明显（风险比0.28，95%置信区间0.14 - 0.55），其次是革兰氏阳性（G）菌感染（风险比0.70，95%置信区间0.50 - 0.97）和革兰氏阴性（G）菌感染（风险比0.89，95%置信区间0.58 - 1.38）。对于G菌感染，RAGE抑制可减少细菌生长和扩散、炎症细胞浸润、血浆细胞因子水平及肺损伤。结论 RAGE抑制似乎对动物模型中败血症的结局有有益影响，尽管不同类型感染之间存在差异。
