Matter Yasser Elsayed, Elhadedy Muhammed Ahmed, Abbas Tarek Medhat, Zahab Mohamed Ahmed, Fouda Mohammed Ashraf, Refaie Ayman Fathi, Sheashaa Hussein Attia, Abbas Mohamed Hamed, Denewar Ahmed Abdelfattah, Nagib Ayman Maher
From the Nephrology Department, Urology and Nephrology Center, Mansoura University, Mansoura, Egypt.
Exp Clin Transplant. 2018 Apr;16(2):133-137. doi: 10.6002/ect.2016.0253. Epub 2017 Jun 5.
Renal transplant is the criterion standard for treatment of end-stage renal disease. The effects of disparities between men and women on renal transplant outcomes have been evaluated in many studies but with debatable results. It has been suggested that female kidney donors have poor outcomes after transplant compared with male kidney donors, especially when implanted in a male recipient. The aim of the study was to evaluate the effects of sex on living-donor kidney transplant outcome.
The data of 979 patients who underwent living-donor kidney transplant from January 2000 to December 2010 at a single center were reviewed retrospectively. The patients were divided into 4 groups according to recipient and donor sex: male donor-to-male recipient (n = 307), male donor-to-female recipient (n = 132), female donor-to-male recipient (n = 411), and female donor-to-female recipient (n = 129). We compared the demographic characteristics, posttransplant rejection and complications, and graft and patient survival rates among the groups.
Male recipients were older than female recipients, whereas male donors were younger than female donors (P < .001). No statistically significant differences were shown regarding recipient body mass index, ischemia time and time to diuresis, and acute and chronic rejection rates between the groups. Graft (P = .947) and patient (P = .421) survival rates were comparable between groups.
Donor and recipient sex had no significant effect on outcomes of living-donor renal allograft recipients.
肾移植是终末期肾病治疗的标准方法。许多研究评估了性别差异对肾移植结果的影响，但结果存在争议。有研究表明，与男性肾供体相比，女性肾供体移植后的结果较差，尤其是移植给男性受者时。本研究的目的是评估性别对活体供肾移植结果的影响。
回顾性分析了2000年1月至2010年12月在单一中心接受活体供肾移植的979例患者的数据。根据受者和供者的性别将患者分为4组：男性供体-男性受者（n = 307）、男性供体-女性受者（n = 132）、女性供体-男性受者（n = 411）和女性供体-女性受者（n = 129）。我们比较了各组的人口统计学特征、移植后排斥反应和并发症以及移植物和患者生存率。
男性受者比女性受者年龄大，而男性供体比女性供体年龄小（P <.001）。各组之间在受者体重指数、缺血时间和利尿时间以及急慢性排斥反应率方面无统计学显著差异。各组之间的移植物（P =.947）和患者（P =.421）生存率相当。
供体和受者性别对活体供肾移植受者的结果无显著影响。
