Department of Otolaryngology-Head and Neck Surgery, Shin Kong Wu Ho-Su Hospital, Taipei, Taiwan.
ENT and Allergy Associates, New York, New York.
J Clin Sleep Med. 2017 Oct 15;13(10):1137-1144. doi: 10.5664/jcsm.6756.
Although drug-induced sleep endoscopy (DISE) is an accepted method to localize upper airway obstruction, it is not known whether all sites identified by DISE must be treated to achieve sufficient apnea-hypopnea index (AHI) improvement. The aim of this study was to compare outcomes for unilevel (upper) versus multilevel DISE collapse patterns in a patient cohort that only underwent modern palatopharyngoplasty. Our hypothesis was that not all tongue base-level obstructions on DISE must be treated.
Thirty-eight patients with mean AHI of 45 events/h underwent DISE followed by palatopharyngoplasty. Outcome was measured by polysomnography or home sleep apnea testing.
Eleven patients (29%) had multilevel, complete tongue base obstruction and nineteen (50%) had no obstruction. These two groups were similar in age, body mass index, and AHI; the complete group had smaller tonsils and higher tongue position. The postoperative success rate and AHI in the group without tongue base obstruction were not significantly different from those of the complete group (68%; 17.4 ± 11.0 versus 73%; 15.4 ± 20.5, > .99). Seventeen patients (45%) had circumferential collapse of velum. The postoperative AHI was higher for patients with circumferential collapse (23.6 ± 15.8 from 55.3 ± 22.1 versus 10.5 ± 9.94 from 36.4 ± 16.7, < .0001), but both groups had clinically and statistically significant AHI reductions.
Patients with multilevel obstruction on DISE, treated with palatopharyngoplasty alone, had similar AHI outcome as those with unilevel obstruction. Multilevel surgery may not be needed in some patients with a multilevel obstruction pattern. Circumferential collapse of velum, however, was associated with a higher residual AHI.
尽管药物诱导睡眠内镜(DISE)是定位上气道阻塞的一种公认方法,但尚不清楚是否必须治疗 DISE 确定的所有部位才能实现足够的睡眠呼吸暂停低通气指数(AHI)改善。本研究的目的是比较在仅接受现代悬雍垂腭咽成形术的患者队列中,单级(上)与多级 DISE 塌陷模式的结果。我们的假设是,并非所有 DISE 上的舌基底水平阻塞都必须治疗。
38 名平均 AHI 为 45 次/小时的患者接受 DISE 检查,然后进行悬雍垂腭咽成形术。通过多导睡眠图或家庭睡眠呼吸暂停测试来衡量结果。
11 名患者(29%)有多级、完全的舌基底阻塞,19 名患者(50%)没有阻塞。这两组在年龄、体重指数和 AHI 方面相似;完全组的扁桃体较小,舌位较高。无舌基底阻塞组的术后成功率和 AHI 与完全组无显著差异(68%;17.4±11.0 与 73%;15.4±20.5,>.99)。17 名患者(45%)有软腭环周塌陷。环周塌陷患者的术后 AHI 更高(23.6±15.8 与 55.3±22.1 相比,10.5±9.94 与 36.4±16.7 相比,<.0001),但两组的 AHI 均有显著的临床和统计学降低。
单独接受悬雍垂腭咽成形术治疗的 DISE 上有多级阻塞的患者,其 AHI 结果与单级阻塞患者相似。在某些有多级阻塞模式的患者中,可能不需要进行多级手术。然而,软腭环周塌陷与更高的残余 AHI 相关。