The binding of bull seminal ribonuclease and its carboxymethylated derivative to human leukaemic cells.

The binding of AS RNase and CM-AS RNase to leukaemic cells from patients with chronic lymphatic leukaemia was detected by indirect immunofluorescence. Leucocytes from normal donors or from patients with other hemoblastoses did not bind RNase. Experiments with lymphocytes from leukaemic patients and the lymphoblastoid cell lines in tissue culture revealed that both AS RNase solutions are probably bound mainly to leukaemic B lymphocytes.